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Surveillance for Patients with Oral Squamous Cell Carcinoma after Complete Surgical Resection as Primary Treatment: A Single-Center Retrospective Cohort Study

SIMPLE SUMMARY: Surveillance methods for oral squamous cell carcinoma (OSCC) patients may be chosen by considering the risk of recurrence. We performed a retrospective cohort study in 324 OSCC patients after complete surgical resection as the primary treatment from 2007 to 2020 at our hospital. Rega...

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Autores principales: Fukumoto, Chonji, Oshima, Ryo, Sawatani, Yuta, Shiraishi, Ryo, Hyodo, Toshiki, Kamimura, Ryouta, Hasegawa, Tomonori, Komiyama, Yuske, Izumi, Sayaka, Fujita, Atsushi, Wakui, Takahiro, Kawamata, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616227/
https://www.ncbi.nlm.nih.gov/pubmed/34830994
http://dx.doi.org/10.3390/cancers13225843
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author Fukumoto, Chonji
Oshima, Ryo
Sawatani, Yuta
Shiraishi, Ryo
Hyodo, Toshiki
Kamimura, Ryouta
Hasegawa, Tomonori
Komiyama, Yuske
Izumi, Sayaka
Fujita, Atsushi
Wakui, Takahiro
Kawamata, Hitoshi
author_facet Fukumoto, Chonji
Oshima, Ryo
Sawatani, Yuta
Shiraishi, Ryo
Hyodo, Toshiki
Kamimura, Ryouta
Hasegawa, Tomonori
Komiyama, Yuske
Izumi, Sayaka
Fujita, Atsushi
Wakui, Takahiro
Kawamata, Hitoshi
author_sort Fukumoto, Chonji
collection PubMed
description SIMPLE SUMMARY: Surveillance methods for oral squamous cell carcinoma (OSCC) patients may be chosen by considering the risk of recurrence. We performed a retrospective cohort study in 324 OSCC patients after complete surgical resection as the primary treatment from 2007 to 2020 at our hospital. Regarding the time to occurrence of postsurgical events, we found that half of cases of local recurrence, cervical lymph node, and distant metastasis occurred within 200 days, and 75% of all these events occurred within 400 days. However, the mean time for second primary cancer was 1589 days. The postsurgical events were detected by imaging examinations earlier than they were by visual examination and palpation. It is desirable to perform FDG-PET/CT within 3–6 months and at 1 year after surgery and to consider CECT as an option in between FDG-PET/CT, while continuing history and physical examinations for about 5 years based on an individual risk assessment. ABSTRACT: Background: The surveillance methods oral squamous cell carcinoma (OSCC) patients may be chosen by considering the risk for recurrence, and it is important to establish appropriate methods during the period in which latent/dormant cancer cells become more apparent. To investigate the appropriate surveillance of patients with OSCC based on the individual risk for recurrence and/or metastasis, we performed a retrospective cohort study after the complete surgical resection of OSCC as the primary treatment. Methods: The study was performed in 324 patients with OSCC who had been primarily treated with surgery from 2007 to 2020 at our hospital. We investigated the period, timing, and methods (visual examination, palpation and imaging using FDG-PET/CT or CECT) for surveillance in each case that comprised postsurgical treatment. Results: Regarding the time to occurrence of postsurgical events, we found that half of cases of local recurrence, cervical lymph node metastasis, and distant metastasis occurred within 200 days, and 75% of all of these events occurred within 400 days. However, the mean time for second primary cancer was 1589 days. The postsurgical events were detected earlier by imaging examinations than they were by visual examination and palpation. Conclusions: For the surveillance of patients with OSCC after primary surgery, it is desirable to perform FDG-PET/CT within 3–6 months and at 1 year after surgery and to consider CECT as an option in between FDG-PET/CT, while continuing history and physical examinations for about 5 years based on individual risk assessment.
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spelling pubmed-86162272021-11-26 Surveillance for Patients with Oral Squamous Cell Carcinoma after Complete Surgical Resection as Primary Treatment: A Single-Center Retrospective Cohort Study Fukumoto, Chonji Oshima, Ryo Sawatani, Yuta Shiraishi, Ryo Hyodo, Toshiki Kamimura, Ryouta Hasegawa, Tomonori Komiyama, Yuske Izumi, Sayaka Fujita, Atsushi Wakui, Takahiro Kawamata, Hitoshi Cancers (Basel) Article SIMPLE SUMMARY: Surveillance methods for oral squamous cell carcinoma (OSCC) patients may be chosen by considering the risk of recurrence. We performed a retrospective cohort study in 324 OSCC patients after complete surgical resection as the primary treatment from 2007 to 2020 at our hospital. Regarding the time to occurrence of postsurgical events, we found that half of cases of local recurrence, cervical lymph node, and distant metastasis occurred within 200 days, and 75% of all these events occurred within 400 days. However, the mean time for second primary cancer was 1589 days. The postsurgical events were detected by imaging examinations earlier than they were by visual examination and palpation. It is desirable to perform FDG-PET/CT within 3–6 months and at 1 year after surgery and to consider CECT as an option in between FDG-PET/CT, while continuing history and physical examinations for about 5 years based on an individual risk assessment. ABSTRACT: Background: The surveillance methods oral squamous cell carcinoma (OSCC) patients may be chosen by considering the risk for recurrence, and it is important to establish appropriate methods during the period in which latent/dormant cancer cells become more apparent. To investigate the appropriate surveillance of patients with OSCC based on the individual risk for recurrence and/or metastasis, we performed a retrospective cohort study after the complete surgical resection of OSCC as the primary treatment. Methods: The study was performed in 324 patients with OSCC who had been primarily treated with surgery from 2007 to 2020 at our hospital. We investigated the period, timing, and methods (visual examination, palpation and imaging using FDG-PET/CT or CECT) for surveillance in each case that comprised postsurgical treatment. Results: Regarding the time to occurrence of postsurgical events, we found that half of cases of local recurrence, cervical lymph node metastasis, and distant metastasis occurred within 200 days, and 75% of all of these events occurred within 400 days. However, the mean time for second primary cancer was 1589 days. The postsurgical events were detected earlier by imaging examinations than they were by visual examination and palpation. Conclusions: For the surveillance of patients with OSCC after primary surgery, it is desirable to perform FDG-PET/CT within 3–6 months and at 1 year after surgery and to consider CECT as an option in between FDG-PET/CT, while continuing history and physical examinations for about 5 years based on individual risk assessment. MDPI 2021-11-21 /pmc/articles/PMC8616227/ /pubmed/34830994 http://dx.doi.org/10.3390/cancers13225843 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fukumoto, Chonji
Oshima, Ryo
Sawatani, Yuta
Shiraishi, Ryo
Hyodo, Toshiki
Kamimura, Ryouta
Hasegawa, Tomonori
Komiyama, Yuske
Izumi, Sayaka
Fujita, Atsushi
Wakui, Takahiro
Kawamata, Hitoshi
Surveillance for Patients with Oral Squamous Cell Carcinoma after Complete Surgical Resection as Primary Treatment: A Single-Center Retrospective Cohort Study
title Surveillance for Patients with Oral Squamous Cell Carcinoma after Complete Surgical Resection as Primary Treatment: A Single-Center Retrospective Cohort Study
title_full Surveillance for Patients with Oral Squamous Cell Carcinoma after Complete Surgical Resection as Primary Treatment: A Single-Center Retrospective Cohort Study
title_fullStr Surveillance for Patients with Oral Squamous Cell Carcinoma after Complete Surgical Resection as Primary Treatment: A Single-Center Retrospective Cohort Study
title_full_unstemmed Surveillance for Patients with Oral Squamous Cell Carcinoma after Complete Surgical Resection as Primary Treatment: A Single-Center Retrospective Cohort Study
title_short Surveillance for Patients with Oral Squamous Cell Carcinoma after Complete Surgical Resection as Primary Treatment: A Single-Center Retrospective Cohort Study
title_sort surveillance for patients with oral squamous cell carcinoma after complete surgical resection as primary treatment: a single-center retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616227/
https://www.ncbi.nlm.nih.gov/pubmed/34830994
http://dx.doi.org/10.3390/cancers13225843
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