Cargando…

Disruption of Mitochondrial Homeostasis: The Role of PINK1 in Parkinson’s Disease

The progressive reduction of the dopaminergic neurons of the substantia nigra is the fundamental process underlying Parkinson’s disease (PD), while the mechanism of susceptibility of this specific neuronal population is largely unclear. Disturbances in mitochondrial function have been recognized as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vizziello, Maria, Borellini, Linda, Franco, Giulia, Ardolino, Gianluca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616241/ https://www.ncbi.nlm.nih.gov/pubmed/34831247 http://dx.doi.org/10.3390/cells10113022

Ejemplares similares

The Roles of PINK1 and Parkin in Parkinson's Disease
por: Jones, Rachel
Publicado: (2010)

PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease
por: Kazlauskaite, Agne, et al.
Publicado: (2015)

Effective Connectivity During Rest and Music Listening: An EEG Study on Parkinson’s Disease
por: Maggioni, Eleonora, et al.
Publicado: (2021)

PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease
por: Ge, Preston, et al.
Publicado: (2020)

Mitophagy and Parkinson's disease: The PINK1–parkin link()
por: Deas, Emma, et al.
Publicado: (2011)

Subclinical myopathic changes in COVID-19
por: Villa, Davide, et al.
Publicado: (2021)

WE-164. Subclinical myopathic changes in Covid-19
por: Villa, Davide, et al.
Publicado: (2022)

Outlook of PINK1/Parkin signaling in molecular etiology of Parkinson’s disease, with insights into Pink1 knockout models
por: Wang, Zhangting, et al.
Publicado: (2023)

In a flurry of PINK, mitochondrial bioenergetics takes a leading role in Parkinson's disease
por: Murphy, Anne N
Publicado: (2009)

PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease
por: Mouton-Liger, Francois, et al.
Publicado: (2017)

The Mitochondrial Kinase PINK1 in Diabetic Kidney Disease
por: Huang, Chunling, et al.
Publicado: (2021)

PINK1: A Bridge between Mitochondria and Parkinson’s Disease
por: Gonçalves, Filipa Barroso, et al.
Publicado: (2021)

PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson’s Disease Pathobiology?
por: Truban, Dominika, et al.
Publicado: (2017)

PINK1 deficiency impairs osteoblast differentiation through aberrant mitochondrial homeostasis
por: Lee, So-Young, et al.
Publicado: (2021)

Loss of Non-Apoptotic Role of Caspase-3 in the PINK1 Mouse Model of Parkinson’s Disease
por: Imbriani, Paola, et al.
Publicado: (2019)

Prospects for the Development of Pink1 and Parkin Activators for the Treatment of Parkinson’s Disease
por: Blagov, Alexander V., et al.
Publicado: (2022)

Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1/PRKN-linked Parkinson’s disease
por: Trinh, Joanne, et al.
Publicado: (2022)

Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism
por: Borsche, Max, et al.
Publicado: (2020)

Mitochondrial Homeostasis and Signaling in Parkinson’s Disease
por: Scorziello, Antonella, et al.
Publicado: (2020)

SIAH proteins regulate the degradation and intra‐mitochondrial aggregation of PINK1: Implications for mitochondrial pathology in Parkinson's disease
por: Abd Elghani, Fatimah, et al.
Publicado: (2022)

New Perception of Mitochondrial Regulatory Pathway in Parkinsonism – Ubiquitin, PINK1, and Parkin
por: Olszewska, Diana Angelika, et al.
Publicado: (2014)

Bioenergetic Consequences of PINK1 Mutations in Parkinson Disease
por: Abramov, Andrey Yurevich, et al.
Publicado: (2011)

αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease
por: Pozo Devoto, Victorio Martin, et al.
Publicado: (2017)

Chaperone-Mediated Autophagy and Mitochondrial Homeostasis in Parkinson's Disease
por: Yang, Ruixin, et al.
Publicado: (2016)

Subclinical myopathic changes in COVID-19
por: Villa, Davide, et al.
Publicado: (2021)

PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis
por: Yang, Weili, et al.
Publicado: (2021)

Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson's disease triggered by mitochondrial stress()
por: Moisoi, Nicoleta, et al.
Publicado: (2014)

Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson’s disease
por: Koentjoro, Brianada, et al.
Publicado: (2017)

Exploring the contribution of the mitochondrial disulfide relay system to Parkinson’s disease: the PINK1/CHCHD4 interplay
por: Arena, Giuseppe, et al.
Publicado: (2021)

The PINK1-Mediated Crosstalk between Neural Cells and the Underlying Link to Parkinson’s Disease
por: Leites, Elvira Pequeno, et al.
Publicado: (2021)

Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease
por: Costa, A C, et al.
Publicado: (2013)

Role of Cleaved PINK1 in Neuronal Development, Synaptogenesis, and Plasticity: Implications for Parkinson’s Disease
por: Soman, Smijin K., et al.
Publicado: (2021)

T313M polymorphism of the PINK1 gene in Parkinson’s disease
por: LUO, QIN, et al.
Publicado: (2014)

Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations
por: Kumar, Atul, et al.
Publicado: (2017)

To be or not to be pink(1): contradictory findings in an animal model for Parkinson’s disease
por: de Haas, Ria, et al.
Publicado: (2019)

Increased cysteine metabolism in PINK1 models of Parkinson's disease
por: Travaglio, Marco, et al.
Publicado: (2023)

Parkinson’s Disease: Are PINK1 Activators Inching Closer to the Clinic?
por: Mehellou, Youcef
Publicado: (2023)

PINK1: From Parkinson’s disease to mitophagy and back again
por: O’Callaghan, Benjamin, et al.
Publicado: (2023)

PINK1-Parkin Pathway Activity Is Regulated by Degradation of PINK1 in the Mitochondrial Matrix
por: Thomas, Ruth E., et al.
Publicado: (2014)

PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control
por: Zhuang, Na, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_s8unhg3p3r320orv9l24l6feq2