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Modulation of FLT3-ITD Localization and Targeting of Distinct Downstream Signaling Pathways as Potential Strategies to Overcome FLT3-Inhibitor Resistance

OBJECTIVES: Internal tandem duplications (ITDs) of the Fms-like tyrosine kinase 3 (FLT3) represent the most frequent molecular aberrations in acute myeloid leukemia (AML) and are associated with an inferior prognosis. The pattern of downstream activation by this constitutively activated receptor tyr...

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Detalles Bibliográficos
Autores principales:	Fleischmann, Maximilian, Fischer, Mike, Schnetzke, Ulf, Fortner, Colin, Kirkpatrick, Joanna, Heidel, Florian H., Hochhaus, Andreas, Scholl, Sebastian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616352/ https://www.ncbi.nlm.nih.gov/pubmed/34831215 http://dx.doi.org/10.3390/cells10112992

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