Cargando…

The Role of Protein SUMOylation in Human Hepatocellular Carcinoma: A Potential Target of New Drug Discovery and Development

SIMPLE SUMMARY: The small ubiquitin-like modifier is a highly conserved post-translational modification protein, mainly found in eukaryotes. Recently, studies have shown that SUMOylation promotes the development of liver cancer. This article summarises the recent literature on SUMOylation and Hepato...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuan, Hongchao, Lu, Yuanjun, Chan, Yau-Tuen, Zhang, Cheng, Wang, Ning, Feng, Yibin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616375/ https://www.ncbi.nlm.nih.gov/pubmed/34830854 http://dx.doi.org/10.3390/cancers13225700

Ejemplares similares

Genipin-activating PPARγ impedes CCR2-mediated macrophage infiltration into postoperative liver to suppress recurrence of hepatocellular carcinoma
por: Wu, Junyu, et al.
Publicado: (2023)

CRISPR-Cas9 library screening approach for anti-cancer drug discovery: overview and perspectives
por: Chan, Yau-Tuen, et al.
Publicado: (2022)

Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy
por: Lu, Yuanjun, et al.
Publicado: (2020)

PIWIL1 governs the crosstalk of cancer cell metabolism and immunosuppressive microenvironment in hepatocellular carcinoma
por: Wang, Ning, et al.
Publicado: (2021)

Thioredoxin-interacting protein-activated intracellular potassium deprivation mediates the anti-tumour effect of a novel histone acetylation inhibitor HL23, a fangchinoline derivative, in human hepatocellular carcinoma
por: Lu, Yuanjun, et al.
Publicado: (2022)

Potential Focal Adhesion Kinase Inhibitors in Management of Cancer: Therapeutic Opportunities from Herbal Medicine
por: Chen, Feiyu, et al.
Publicado: (2022)

The Role of AMP-Activated Protein Kinase as a Potential Target of Treatment of Hepatocellular Carcinoma
por: Jiang, Xue, et al.
Publicado: (2019)

Epigenetic regulation of ferroptosis via ETS1/miR-23a-3p/ACSL4 axis mediates sorafenib resistance in human hepatocellular carcinoma
por: Lu, Yuanjun, et al.
Publicado: (2022)

Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis
por: Chan, Yau-tuen, et al.
Publicado: (2023)

Circulating tumor cells in the early detection of human cancers
por: Feng, Zixin, et al.
Publicado: (2022)

The toxicology and detoxification of Aconitum: traditional and modern views
por: Chan, Yau-Tuen, et al.
Publicado: (2021)

Systematic Review with Meta-Analysis: Effectiveness and Safety of Acupuncture as Adjuvant Therapy for Side Effects Management in Drug Therapy-Receiving Breast Cancer Patients
por: Chan, Yau-Tuen, et al.
Publicado: (2021)

Targeting Hepatic Stellate Cells for the Treatment of Liver Fibrosis by Natural Products: Is It the Dawning of a New Era?
por: Chan, Yau-Tuen, et al.
Publicado: (2020)

Characterization of cuproptosis in gastric cancer and relationship with clinical and drug reactions
por: Chen, Guoming, et al.
Publicado: (2023)

GPC2 Is a Potential Diagnostic, Immunological, and Prognostic Biomarker in Pan-Cancer
por: Chen, Guoming, et al.
Publicado: (2022)

Identification of WT1 as determinant of heptatocellular carcinoma and its inhibition by Chinese herbal medicine Salvia chinensis Benth and its active ingredient protocatechualdehyde
por: Wang, Ning, et al.
Publicado: (2017)

Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development
por: Deng, Rong, et al.
Publicado: (2015)

Lysyl Oxidase‐Like 4 Fosters an Immunosuppressive Microenvironment During Hepatocarcinogenesis
por: Tan, Hor‐Yue, et al.
Publicado: (2021)

Deciphering hepatocellular carcinoma through metabolomics: from biomarker discovery to therapy evaluation
por: Guo, Wei, et al.
Publicado: (2018)

SUMOylation in fungi: A potential target for intervention
por: Gupta, Dipika, et al.
Publicado: (2020)

Ancient Chinese Medicine Herbal Formula Huanglian Jiedu Decoction as a Neoadjuvant Treatment of Chemotherapy by Improving Diarrhea and Tumor Response
por: Chan, Yau-Tuen, et al.
Publicado: (2020)

Targeting SUMOylation in Plasmodium as a Potential Target for Malaria Therapy
por: Sumam de Oliveira, Daffiny, et al.
Publicado: (2021)

Discovery of NKCC1 as a potential therapeutic target to inhibit hepatocellular carcinoma cell growth and metastasis
por: Zhou, Yaya, et al.
Publicado: (2017)

A novel prognostic signature for hepatocellular carcinoma based on SUMOylation-related genes
por: Wang, Jianping, et al.
Publicado: (2023)

Drugging SUMOylation for neuroprotection and oncotherapy
por: Bernstock, Joshua D., et al.
Publicado: (2018)

Advances in drug development for hepatocellular carcinoma: clinical trials and potential therapeutic targets
por: Luo, Xiang-Yuan, et al.
Publicado: (2021)

Identification and functional characterization of potential oncofetal targets in human hepatocellular carcinoma
por: Li, Mei-Mei, et al.
Publicado: (2022)

SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T
por: Tao, Yifeng, et al.
Publicado: (2020)

HAMP as a Potential Diagnostic, PD-(L)1 Immunotherapy Sensitivity and Prognostic Biomarker in Hepatocellular Carcinoma
por: Chen, Guoming, et al.
Publicado: (2023)

New Natural Pigment Fraction Isolated from Saw Palmetto: Potential for Adjuvant Therapy of Hepatocellular Carcinoma
por: Tan, Hor-Yue, et al.
Publicado: (2016)

Regulation of SUMOylation Targets Associated With Wnt/β-Catenin Pathway
por: Fan, Linlin, et al.
Publicado: (2022)

The Significance of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma: Real-Time Monitoring and Moving Targets for Cancer Therapy
por: Chen, Feiyu, et al.
Publicado: (2020)

Novel molecular targets in hepatocellular carcinoma
por: Chow, Ariel Ka-Man, et al.
Publicado: (2020)

The Role and Mechanisms of Selenium Supplementation on Fatty Liver-Associated Disorder
por: Xu, Lin, et al.
Publicado: (2022)

Both SUMOylation and ubiquitination of TFE3 fusion protein regulated by androgen receptor are the potential target in the therapy of Xp11.2 translocation renal cell carcinoma
por: Liu, Ning, et al.
Publicado: (2022)

Strategies to Identify Recognition Signals and Targets of SUMOylation
por: Da Silva-Ferrada, Elisa, et al.
Publicado: (2012)

SUMOylation in Glioblastoma: A Novel Therapeutic Target
por: Fox, Brandon M., et al.
Publicado: (2019)

SUMOylation as a Therapeutic Target for Myocardial Infarction
por: Zhao, Wei, et al.
Publicado: (2021)

Drug Discovery Using Evolutionary Similarities in Chemical Binding to Inhibit Patient-Derived Hepatocellular Carcinoma
por: Lim, Jin Hong, et al.
Publicado: (2022)

Up-Regulation of TIMP-1 by Genipin Inhibits MMP-2 Activities and Suppresses the Metastatic Potential of Human Hepatocellular Carcinoma
por: Wang, Ning, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_s9hm437458u1e46saqli67k5tu