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Fluctuations in AKT and PTEN Activity Are Linked by the E3 Ubiquitin Ligase cCBL

3-Poly-phosphoinositides (PIP(3)) regulate cell survival, division, and migration. Both PI3-kinase (phosphoinositide-3-kinase) and PTEN (phosphatase and tensin-homolog in chromosome 10) control PIP(3) levels, but the mechanisms connecting PI3-kinase and PTEN are unknown. Using non-transformed cells,...

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Detalles Bibliográficos
Autores principales:	Olazábal-Morán, Manuel, Sánchez-Ortega, Miriam, Martínez-Muñoz, Laura, Hernández, Carmen, Rodríguez, Manuel S., Mellado, Mario, Carrera, Ana C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616390/ https://www.ncbi.nlm.nih.gov/pubmed/34831026 http://dx.doi.org/10.3390/cells10112803

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