Cargando…

Impact of Chromatin Dynamics and DNA Repair on Genomic Stability and Treatment Resistance in Pediatric High-Grade Gliomas

SIMPLE SUMMARY: Pediatric high-grade gliomas (pHGGs) are the leading cause of mortality in pediatric neuro-oncology, due in great part to treatment resistance driven by complex DNA repair mechanisms. pHGGs have recently been divided into molecular subtypes based on mutations affecting the N-terminal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pinto, Lia, Baidarjad, Hanane, Entz-Werlé, Natacha, Van Dyck, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616465/ https://www.ncbi.nlm.nih.gov/pubmed/34830833 http://dx.doi.org/10.3390/cancers13225678

Ejemplares similares

HGG-34. A DNA DAMAGE REPAIR SIGNATURE IN PRIMARY AND RECURRENT PEDIATRIC HIGH-GRADE GLIOMAS: PROGNOSTIC AND THERAPEUTIC VALUE
por: Entz-Werle, Natacha, et al.
Publicado: (2021)

A DNA Repair and Cell Cycle Gene Expression Signature in Pediatric High-Grade Gliomas: Prognostic and Therapeutic Value
por: Entz-Werlé, Natacha, et al.
Publicado: (2021)

HGG-36. HIF-2: A NEW DRUG TARGET IN PEDIATRIC HIGH-GRADE GLIOMA WITH PROMISING PRECLINICAL RESULTS
por: Fuchs, Quentin, et al.
Publicado: (2020)

Hypoxia Inducible Factors’ Signaling in Pediatric High-Grade Gliomas: Role, Modelization and Innovative Targeted Approaches
por: Fuchs, Quentin, et al.
Publicado: (2020)

LGG-16. Retrospective and integrative analyses of molecular characteristics and their specific imaging parameters in pediatric grade 1 gliomas.
por: Courant, Marie, et al.
Publicado: (2022)

Role of Topoisomerases in Pediatric High Grade Osteosarcomas: TOP2A Gene Is One of the Unique Molecular Biomarkers of Chemoresponse
por: Nguyen, Aurelia, et al.
Publicado: (2013)

Chromatin mutations in pediatric high grade gliomas
por: Voon, Hsiao P. J., et al.
Publicado: (2023)

Characterization of the transcriptional and metabolic responses of pediatric high grade gliomas to mTOR-HIF-1α axis inhibition
por: Nguyen, Aurélia, et al.
Publicado: (2017)

Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients
por: Izquierdo, Elisa, et al.
Publicado: (2021)

Mutations in chromatin machinery and pediatric high-grade glioma
por: Lulla, Rishi R., et al.
Publicado: (2016)

EPCT-11. PHASE 1 STUDY OF FLUVASTATIN-CELECOXIB COMBINATION IN CHILDREN WITH RELAPSING/REFRACTORY OPTICO-CHIASMATIC LOW-GRADE GLIOMA OR HIGH-GRADE GLIOMAS (FLUVABREX): FINAL RESULTS
por: Andrew, Nicolas, et al.
Publicado: (2020)

HGG-39. Integrative analyses of BRAFp.v600e mutated gliomas: from epigenetic to metabolic characteristics
por: Lhermitte, Benoit, et al.
Publicado: (2022)

Phase I Study of a Combination of Fluvastatin and Celecoxib in Children with Relapsing/Refractory Low-Grade or High-Grade Glioma (FLUVABREX)
por: Leblond, Pierre, et al.
Publicado: (2023)

Sirolimus Pharmacokinetics Variability Points to the Relevance of Therapeutic Drug Monitoring in Pediatric Oncology
por: Sabo, Amelia-Naomi, et al.
Publicado: (2021)

Chromatin Dynamics in Genome Stability: Roles in Suppressing Endogenous DNA Damage and Facilitating DNA Repair
por: Nair, Nidhi, et al.
Publicado: (2017)

TBIO-17. INTEGRATIVE ANALYSES OF BRAFv600e MUTATED GLIOMAS: FROM MOLECULAR BIOLOGY TO RADIOLOGY AND TREATMENTS
por: Lhermitte, Benoit, et al.
Publicado: (2020)

Together Intra-Tumor Hypoxia and Macrophagic Immunity Are Driven Worst Outcome in Pediatric High-Grade Osteosarcomas
por: Nazon, Charlotte, et al.
Publicado: (2022)

Metronomic Four-Drug Regimen Has Anti-tumor Activity in Pediatric Low-Grade Glioma; The Results of a Phase II Clinical Trial
por: Verschuur, Arnauld, et al.
Publicado: (2018)

DIPG-30. HIF2 OVEREXPRESSION DICTATES AGGRESSIVENESS ADDITIONALLY TO TP53 MUTATIONS IN H3.3K27M PEDIATRIC HIGH-GRADE GLIOMAS THROUGH RAS-MAPK AND WNT/BCATENIN PATHWAYS
por: Fuchs, Quentin, et al.
Publicado: (2023)

Chromatin and nucleosome dynamics in DNA damage and repair
por: Hauer, Michael H., et al.
Publicado: (2017)

RARE-19. PEDIATRIC HIGH GRADE GLIOMA WITH DNA REPAIR PATHWAY ABERRATIONS, CLINICAL CHARACTERISTICS AND OUTCOME
por: Baig, Muhammad, et al.
Publicado: (2020)

p16 Immunohistochemical Expression as a Surrogate Assessment of CDKN2A Alteration in Gliomas Leading to Prognostic Significances
por: Geyer, Lucas, et al.
Publicado: (2023)

Focus on Hypoxia-Related Pathways in Pediatric Osteosarcomas and Their Druggability
por: Pierrevelcin, Marina, et al.
Publicado: (2020)

DIPG-33. P16 IMMUNOHISTOCHEMICAL EXPRESSION AS A SURROGATE ASSESSMENT OF CDKN2A ALTERATION IN GLIOMAS LEADING TO PROGNOSTIC SIGNIFICANCES
por: Geyer, Lucas, et al.
Publicado: (2023)

Glioblastoma Metabolism: Insights and Therapeutic Strategies
por: Bernhard, Chloé, et al.
Publicado: (2023)

Pediatric Low-Grade Gliomas
por: Collins, Kelly L., et al.
Publicado: (2020)

HGG-44. DEFECTS OF MISMATCH REPAIR PROTEINS IN PEDIATRIC HIGH GRADE GLIOMAS
por: Haberler, Christine, et al.
Publicado: (2020)

The Subventricular Zone, a Hideout for Adult and Pediatric High-Grade Glioma Stem Cells
por: Lombard, Arnaud, et al.
Publicado: (2021)

Molecular Heterogeneity in BRAF-Mutant Gliomas: Diagnostic, Prognostic, and Therapeutic Implications
por: Lhermitte, Benoit, et al.
Publicado: (2023)

From dynamic chromatin architecture to DNA damage repair and back
por: Fabre, Emmanuelle, et al.
Publicado: (2018)

Radio-Resistance and DNA Repair in Pediatric Diffuse Midline Gliomas
por: Pedersen, Henriette, et al.
Publicado: (2020)

Maintenance of genome stability in plants: repairing DNA double strand breaks and chromatin structure stability
por: Roy, Sujit
Publicado: (2014)

Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric H3.3-Mutated Gliomas Recreate the Patient Tumor Complexity
por: Blandin, Anne-Florence, et al.
Publicado: (2019)

Pakistan National Guidelines for Pediatric High-Grade Gliomas
por: Bashir, Farrah, et al.
Publicado: (2023)

A novel DNA repair‐related nomogram predicts survival in low‐grade gliomas
por: Li, Guanzhang, et al.
Publicado: (2020)

The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair
por: Xu, Ye, et al.
Publicado: (2010)

SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair
por: McCord, Ronald A., et al.
Publicado: (2009)

Medical Treatment of Pediatric Low-Grade Glioma
por: Lim, Yeon Jung
Publicado: (2022)

Chromatin structure and DNA damage repair
por: Dinant, Christoffel, et al.
Publicado: (2008)

Complex Chromatin Motions for DNA Repair
por: Miné-Hattab, Judith, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_se2u4rufktbchfj6slqcln81c4