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The Radiotherapy Role in the Multidisciplinary Management of Locally Advanced Vulvar Cancer: A Multidisciplinary VulCan Team Review
SIMPLE SUMMARY: Locally advanced vulvar cancer (LAVC) requires a multidisciplinary management. The aim of this paper is to conduct a review of all relevant studies regarding the role of radiotherapy in LAVC. Based on the available evidence, radiotherapy, with or without concurrent chemotherapy, has...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616490/ https://www.ncbi.nlm.nih.gov/pubmed/34830901 http://dx.doi.org/10.3390/cancers13225747 |
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author | Tagliaferri, Luca Lancellotta, Valentina Casà, Calogero Fragomeni, Simona Maria Ferioli, Martina Gentileschi, Stefano Caretto, Anna Amelia Corrado, Giacomo Gui, Benedetta Colloca, Giuseppe Ferdinando Gambacorta, Maria Antonietta Morganti, Alessio Giuseppe Garganese, Giorgia Macchia, Gabriella |
author_facet | Tagliaferri, Luca Lancellotta, Valentina Casà, Calogero Fragomeni, Simona Maria Ferioli, Martina Gentileschi, Stefano Caretto, Anna Amelia Corrado, Giacomo Gui, Benedetta Colloca, Giuseppe Ferdinando Gambacorta, Maria Antonietta Morganti, Alessio Giuseppe Garganese, Giorgia Macchia, Gabriella |
author_sort | Tagliaferri, Luca |
collection | PubMed |
description | SIMPLE SUMMARY: Locally advanced vulvar cancer (LAVC) requires a multidisciplinary management. The aim of this paper is to conduct a review of all relevant studies regarding the role of radiotherapy in LAVC. Based on the available evidence, radiotherapy, with or without concurrent chemotherapy, has a relevant role in neoadjuvant, adjuvant or exclusive treatments. A multidisciplinary and multidimensional assessment can also be useful to identify the most suitable approach, in view of a better treatment personalization. ABSTRACT: Locally advanced vulvar cancer (LAVC) is a challenging disease, requiring multidisciplinary management. The aim of this review is to propose an integrated clinical approach including radiotherapy (RT) in the multidisciplinary management of LAVC to customize the treatment. A review of the literature was conducted on PubMed, Scopus, and Cochrane library to acquire all relevant studies on RT in LAVC. Based on the available evidence, RT, with or without concurrent chemotherapy, has a relevant role as adjuvant and exclusive treatment or in the neoadjuvant setting. However, multicentric prospective trials are needed to define the best treatment options based on tumor and patient characteristics. A multidisciplinary and multidimensional assessment can also be useful to identify the most suitable approach, considering patients’ age and comorbidities, in view of a better treatment personalization. |
format | Online Article Text |
id | pubmed-8616490 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86164902021-11-26 The Radiotherapy Role in the Multidisciplinary Management of Locally Advanced Vulvar Cancer: A Multidisciplinary VulCan Team Review Tagliaferri, Luca Lancellotta, Valentina Casà, Calogero Fragomeni, Simona Maria Ferioli, Martina Gentileschi, Stefano Caretto, Anna Amelia Corrado, Giacomo Gui, Benedetta Colloca, Giuseppe Ferdinando Gambacorta, Maria Antonietta Morganti, Alessio Giuseppe Garganese, Giorgia Macchia, Gabriella Cancers (Basel) Review SIMPLE SUMMARY: Locally advanced vulvar cancer (LAVC) requires a multidisciplinary management. The aim of this paper is to conduct a review of all relevant studies regarding the role of radiotherapy in LAVC. Based on the available evidence, radiotherapy, with or without concurrent chemotherapy, has a relevant role in neoadjuvant, adjuvant or exclusive treatments. A multidisciplinary and multidimensional assessment can also be useful to identify the most suitable approach, in view of a better treatment personalization. ABSTRACT: Locally advanced vulvar cancer (LAVC) is a challenging disease, requiring multidisciplinary management. The aim of this review is to propose an integrated clinical approach including radiotherapy (RT) in the multidisciplinary management of LAVC to customize the treatment. A review of the literature was conducted on PubMed, Scopus, and Cochrane library to acquire all relevant studies on RT in LAVC. Based on the available evidence, RT, with or without concurrent chemotherapy, has a relevant role as adjuvant and exclusive treatment or in the neoadjuvant setting. However, multicentric prospective trials are needed to define the best treatment options based on tumor and patient characteristics. A multidisciplinary and multidimensional assessment can also be useful to identify the most suitable approach, considering patients’ age and comorbidities, in view of a better treatment personalization. MDPI 2021-11-17 /pmc/articles/PMC8616490/ /pubmed/34830901 http://dx.doi.org/10.3390/cancers13225747 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tagliaferri, Luca Lancellotta, Valentina Casà, Calogero Fragomeni, Simona Maria Ferioli, Martina Gentileschi, Stefano Caretto, Anna Amelia Corrado, Giacomo Gui, Benedetta Colloca, Giuseppe Ferdinando Gambacorta, Maria Antonietta Morganti, Alessio Giuseppe Garganese, Giorgia Macchia, Gabriella The Radiotherapy Role in the Multidisciplinary Management of Locally Advanced Vulvar Cancer: A Multidisciplinary VulCan Team Review |
title | The Radiotherapy Role in the Multidisciplinary Management of Locally Advanced Vulvar Cancer: A Multidisciplinary VulCan Team Review |
title_full | The Radiotherapy Role in the Multidisciplinary Management of Locally Advanced Vulvar Cancer: A Multidisciplinary VulCan Team Review |
title_fullStr | The Radiotherapy Role in the Multidisciplinary Management of Locally Advanced Vulvar Cancer: A Multidisciplinary VulCan Team Review |
title_full_unstemmed | The Radiotherapy Role in the Multidisciplinary Management of Locally Advanced Vulvar Cancer: A Multidisciplinary VulCan Team Review |
title_short | The Radiotherapy Role in the Multidisciplinary Management of Locally Advanced Vulvar Cancer: A Multidisciplinary VulCan Team Review |
title_sort | radiotherapy role in the multidisciplinary management of locally advanced vulvar cancer: a multidisciplinary vulcan team review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616490/ https://www.ncbi.nlm.nih.gov/pubmed/34830901 http://dx.doi.org/10.3390/cancers13225747 |
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