Evaluation of Hedgehog Pathway Inhibition on Nevoid Basal Cell Carcinoma Syndrome Fibroblasts and Basal Cell Carcinoma-Associated Fibroblasts: Are Vismodegib and Sonidegib Useful to Target Cancer-Prone Fibroblasts?

SIMPLE SUMMARY: Nevoid basal cell carcinoma syndrome (NBCCS) is a genetic disorder of autosomal dominant inheritance that dramatically predisposes a patient to the formation of basal cell carcinoma (BCC) due to causative mutations in several genes associated with the Hedgehog (Hh) pathway. Somatic m...

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Detalles Bibliográficos
Autores principales: Eibenschutz, Laura, Caputo, Silvia, Camera, Emanuela, Carbone, Anna, Silipo, Vitaliano, Migliano, Emilia, Aurizi, Caterina, Cota, Carlo, Frascione, Pasquale, Bellei, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616531/
https://www.ncbi.nlm.nih.gov/pubmed/34831015
http://dx.doi.org/10.3390/cancers13225858

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