A Personalized Neoantigen Vaccine in Combination with Platinum-Based Chemotherapy Induces a T-Cell Response Coinciding with a Complete Response in Endometrial Carcinoma

SIMPLE SUMMARY: We investigated the feasibility and immunogenicity of an autologous Dendritic Cell (DC) vaccine pulsed with peptide neoantigens in combination with a standard of care regimen. The vaccine program took place in a serous endometrial mismatch repair (MMR) deficiency setting. We demonstr...

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Detalles Bibliográficos
Autores principales: Harari, Alexandre, Sarivalasis, Apostolos, de Jonge, Kaat, Thierry, Anne-Christine, Huber, Florian, Boudousquie, Caroline, Rossier, Laetitia, Orcurto, Angela, Imbimbo, Martina, Baumgaertner, Petra, Bassani-Sternberg, Michal, Kandalaft, Lana E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616532/
https://www.ncbi.nlm.nih.gov/pubmed/34830955
http://dx.doi.org/10.3390/cancers13225801

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