Adaptation to Chronic-Cycling Hypoxia Renders Cancer Cells Resistant to MTH1-Inhibitor Treatment Which Can Be Counteracted by Glutathione Depletion

Tumor hypoxia and hypoxic adaptation of cancer cells represent major barriers to successful cancer treatment. We revealed that improved antioxidant capacity contributes to increased radioresistance of cancer cells with tolerance to chronic-cycling severe hypoxia/reoxygenation stress. We hypothesized...

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Detalles Bibliográficos
Autores principales: Hansel, Christine, Hlouschek, Julian, Xiang, Kexu, Melnikova, Margarita, Thomale, Juergen, Helleday, Thomas, Jendrossek, Verena, Matschke, Johann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616547/
https://www.ncbi.nlm.nih.gov/pubmed/34831264
http://dx.doi.org/10.3390/cells10113040

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