TANK prevents IFN-dependent fatal diffuse alveolar hemorrhage by suppressing DNA-cGAS aggregation

Diffuse alveolar hemorrhage (DAH) is one of the serious complications associated with systemic lupus erythematosus, an autoimmune disease whose pathogenesis involves type I IFNs and cytokines. Here, we show that TANK, a negative regulator of the NF-κB signaling via suppression of TRAF6 ubiquitinatio...

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Detalles Bibliográficos
Autores principales: Wakabayashi, Atsuko, Yoshinaga, Masanori, Takeuchi, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616552/
https://www.ncbi.nlm.nih.gov/pubmed/34819357
http://dx.doi.org/10.26508/lsa.202101067

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