Cargando…

The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics

The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed membrane protein consisting of ion channel and protein kinase domains. TRPM7 plays a fundamental role in the cellular uptake of divalent cations such as Zn(2+), Mg(2+), and Ca(2+), and thus shapes cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kollewe, Astrid, Chubanov, Vladimir, Tseung, Fong Tsuen, Correia, Leonor, Schmidt, Eva, Rössig, Anna, Zierler, Susanna, Haupt, Alexander, Müller, Catrin Swantje, Bildl, Wolfgang, Schulte, Uwe, Nicke, Annette, Fakler, Bernd, Gudermann, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616561/ https://www.ncbi.nlm.nih.gov/pubmed/34766907 http://dx.doi.org/10.7554/eLife.68544

Ejemplares similares

TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg(2+) and Mg·ATP
por: Ferioli, Silvia, et al.
Publicado: (2017)

Structural mechanism of TRPM7 channel regulation by intracellular magnesium
por: Schmidt, Eva, et al.
Publicado: (2022)

Conformational regulation and target-myristoyl switch of calcineurin B homologous protein 3
por: Becker, Florian, et al.
Publicado: (2023)

Mapping TRPM7 Function by NS8593
por: Chubanov, Vladimir, et al.
Publicado: (2020)

Structural mechanisms of TRPM7 activation and inhibition
por: Nadezhdin, Kirill D., et al.
Publicado: (2023)

Natural and Synthetic Modulators of the TRPM7 Channel
por: Chubanov, Vladimir, et al.
Publicado: (2014)

Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing
por: Thapa, Dibesh, et al.
Publicado: (2021)

Improved ANAP incorporation and VCF analysis reveal details of P2X7 current facilitation and a limited conformational interplay between ATP binding and the intracellular ballast domain
por: Durner, Anna, et al.
Publicado: (2023)

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function
por: Gerndt, Susanne, et al.
Publicado: (2020)

Drosophila TRPM Channel Is Essential for the Control of Extracellular Magnesium Levels
por: Hofmann, Thomas, et al.
Publicado: (2010)

TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut
por: Romagnani, Andrea, et al.
Publicado: (2017)

TRPM7 kinase is required for insulin production and compensatory islet responses during obesity
por: Khajavi, Noushafarin, et al.
Publicado: (2023)

Inactivation of TRPM7 Kinase Targets AKT Signaling and Cyclooxygenase-2 Expression in Human CML Cells
por: Hoeger, Birgit, et al.
Publicado: (2023)

The Channel-Kinase TRPM7 as Novel Regulator of Immune System Homeostasis
por: Nadolni, Wiebke, et al.
Publicado: (2018)

TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells
por: Kaske, Silke, et al.
Publicado: (2007)

TRPM7 restrains plasmin activity and promotes transforming growth factor-β1 signaling in primary human lung fibroblasts
por: Zeitlmayr, Sarah, et al.
Publicado: (2022)

TRPM7 Kinase Is Essential for Neutrophil Recruitment and Function via Regulation of Akt/mTOR Signaling
por: Nadolni, Wiebke, et al.
Publicado: (2021)

Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival
por: Chubanov, Vladimir, et al.
Publicado: (2016)

Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture
por: Stritt, Simon, et al.
Publicado: (2016)

TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival
por: Mittermeier, Lorenz, et al.
Publicado: (2019)

Cell-surface tethered promiscuous biotinylators enable comparative small-scale surface proteomic analysis of human extracellular vesicles and cells
por: Kirkemo, Lisa L, et al.
Publicado: (2022)

Structural diversity of oligomeric β-propellers with different numbers of identical blades
por: Afanasieva, Evgenia, et al.
Publicado: (2019)

Homo-oligomerization of the human adenosine A(2A) receptor is driven by the intrinsically disordered C-terminus
por: Nguyen, Khanh Dinh Quoc, et al.
Publicado: (2021)

Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia
por: Hu, Xuchen, et al.
Publicado: (2019)

A polyomavirus peptide binds to the capsid VP1 pore and has potent antiviral activity against BK and JC polyomaviruses
por: Kane, Joshua R, et al.
Publicado: (2020)

GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients
por: Hu, Xuchen, et al.
Publicado: (2019)

Elucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice
por: Ryazanova, Lillia V., et al.
Publicado: (2014)

TRPM7 is essential for Mg(2+) homeostasis in mammals
por: Ryazanova, Lillia V., et al.
Publicado: (2010)

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
por: Haupt, Caroline, et al.
Publicado: (2017)

Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing
por: Zhang, Li, et al.
Publicado: (2015)

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
por: Overman, Jeroen, et al.
Publicado: (2017)

Structural basis for the recognition of spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in splicing regulation
por: Mourão, André, et al.
Publicado: (2016)

The gating cycle of a K(+) channel at atomic resolution
por: Cuello, Luis G, et al.
Publicado: (2017)

CK1/Doubletime activity delays transcription activation in the circadian clock
por: Top, Deniz, et al.
Publicado: (2018)

In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress
por: Kopp, Megan C, et al.
Publicado: (2018)

eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast
por: Martin-Marcos, Pilar, et al.
Publicado: (2017)

Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure
por: Gao, Jieqiong, et al.
Publicado: (2018)

Gene network analysis identifies a central post-transcriptional regulator of cellular stress survival
por: Tien, Matthew, et al.
Publicado: (2018)

Allosteric mechanism of the V. vulnificus adenine riboswitch resolved by four-dimensional chemical mapping
por: Tian, Siqi, et al.
Publicado: (2018)

Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima
por: Morgunova, Ekaterina, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_dptfcuvclguurebv6m2crumq0t