Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice

The insulin-degrading enzyme (IDE) is a metalloendopeptidase with a high affinity for insulin. Human genetic polymorphisms in Ide have been linked to increased risk for T2DM. In mice, hepatic Ide ablation causes glucose intolerance and insulin resistance when mice are fed a regular diet. OBJECTIVE:...

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Detalles Bibliográficos
Autores principales: Merino, Beatriz, Fernández-Díaz, Cristina M., Parrado-Fernández, Cristina, González-Casimiro, Carlos M., Postigo-Casado, Tamara, Lobatón, Carmen D., Leissring, Malcolm A., Cózar-Castellano, Irene, Perdomo, Germán
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616598/
https://www.ncbi.nlm.nih.gov/pubmed/32916153
http://dx.doi.org/10.1016/j.metabol.2020.154352

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