Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus

AIM: To assess the efficacy and safety of accelerated corneal cross-linking in the treatment of pediatric keratoconus. METHOD: In this retrospective case series, 29 eyes of 20 pediatric patients with keratoconus underwent accelerated corneal cross-linking. Treatment was delivered at 10 mW/cm(2) for...

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Autores principales: Salman, Abdelrahman, Darwish, Taym, Ghabra, Marwan, Kailani, Obeda, Khalil, Hussam, Shaaban, Rafea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616643/
https://www.ncbi.nlm.nih.gov/pubmed/34840821
http://dx.doi.org/10.1155/2021/1851883
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author Salman, Abdelrahman
Darwish, Taym
Ghabra, Marwan
Kailani, Obeda
Khalil, Hussam
Shaaban, Rafea
author_facet Salman, Abdelrahman
Darwish, Taym
Ghabra, Marwan
Kailani, Obeda
Khalil, Hussam
Shaaban, Rafea
author_sort Salman, Abdelrahman
collection PubMed
description AIM: To assess the efficacy and safety of accelerated corneal cross-linking in the treatment of pediatric keratoconus. METHOD: In this retrospective case series, 29 eyes of 20 pediatric patients with keratoconus underwent accelerated corneal cross-linking. Treatment was delivered at 10 mW/cm(2) for 9 minutes with a total dose of 5.4 J/cm(2). Clinical evaluation included visual acuities and refractive and Scheimpflug corneal tomography assessments. All patients with a minimum follow-up duration of 24 months were included in the study. RESULTS: Mean ± standard deviation age was 15.41 ± 2.13 years (range: 8 to 18 years). Uncorrected distance visual acuity improved significantly from 0.56 ± 0.28 to 0.42 ± 0.29 logMAR (P=0.0003), and corrected distance visual acuity improved significantly from 0.34 ± 0.23 to 0.28 ± 0.22 logMAR (P=0.014). The mean manifest refraction spherical equivalent value was significantly reduced (−0.59 ± 0.95 D, P=0.0024). While mean flat keratometry and steep keratometry values were not significantly altered (P > 0.05 for both), the mean maximum keratometry value was significantly decreased from 56.97 ± 5.24 D preoperatively to 55.84 ± 5.37 D at 24 months postoperatively (P=0.003). Maximum keratometry had progressed by >1 D in two eyes (6.89%). Permanent corneal haze was reported in one case (3.44%). CONCLUSION: Our 24-month follow-up demonstrated that accelerated corneal cross-linking appears to halt the progression of keratoconus in pediatric patients without apparent complications. Uncorrected and corrected distance visual acuities were also improved.
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spelling pubmed-86166432021-11-26 Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus Salman, Abdelrahman Darwish, Taym Ghabra, Marwan Kailani, Obeda Khalil, Hussam Shaaban, Rafea J Ophthalmol Research Article AIM: To assess the efficacy and safety of accelerated corneal cross-linking in the treatment of pediatric keratoconus. METHOD: In this retrospective case series, 29 eyes of 20 pediatric patients with keratoconus underwent accelerated corneal cross-linking. Treatment was delivered at 10 mW/cm(2) for 9 minutes with a total dose of 5.4 J/cm(2). Clinical evaluation included visual acuities and refractive and Scheimpflug corneal tomography assessments. All patients with a minimum follow-up duration of 24 months were included in the study. RESULTS: Mean ± standard deviation age was 15.41 ± 2.13 years (range: 8 to 18 years). Uncorrected distance visual acuity improved significantly from 0.56 ± 0.28 to 0.42 ± 0.29 logMAR (P=0.0003), and corrected distance visual acuity improved significantly from 0.34 ± 0.23 to 0.28 ± 0.22 logMAR (P=0.014). The mean manifest refraction spherical equivalent value was significantly reduced (−0.59 ± 0.95 D, P=0.0024). While mean flat keratometry and steep keratometry values were not significantly altered (P > 0.05 for both), the mean maximum keratometry value was significantly decreased from 56.97 ± 5.24 D preoperatively to 55.84 ± 5.37 D at 24 months postoperatively (P=0.003). Maximum keratometry had progressed by >1 D in two eyes (6.89%). Permanent corneal haze was reported in one case (3.44%). CONCLUSION: Our 24-month follow-up demonstrated that accelerated corneal cross-linking appears to halt the progression of keratoconus in pediatric patients without apparent complications. Uncorrected and corrected distance visual acuities were also improved. Hindawi 2021-11-18 /pmc/articles/PMC8616643/ /pubmed/34840821 http://dx.doi.org/10.1155/2021/1851883 Text en Copyright © 2021 Abdelrahman Salman et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Salman, Abdelrahman
Darwish, Taym
Ghabra, Marwan
Kailani, Obeda
Khalil, Hussam
Shaaban, Rafea
Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus
title Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus
title_full Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus
title_fullStr Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus
title_full_unstemmed Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus
title_short Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus
title_sort clinical outcomes of accelerated corneal cross-linking for pediatric keratoconus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616643/
https://www.ncbi.nlm.nih.gov/pubmed/34840821
http://dx.doi.org/10.1155/2021/1851883
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