Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus
AIM: To assess the efficacy and safety of accelerated corneal cross-linking in the treatment of pediatric keratoconus. METHOD: In this retrospective case series, 29 eyes of 20 pediatric patients with keratoconus underwent accelerated corneal cross-linking. Treatment was delivered at 10 mW/cm(2) for...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616643/ https://www.ncbi.nlm.nih.gov/pubmed/34840821 http://dx.doi.org/10.1155/2021/1851883 |
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author | Salman, Abdelrahman Darwish, Taym Ghabra, Marwan Kailani, Obeda Khalil, Hussam Shaaban, Rafea |
author_facet | Salman, Abdelrahman Darwish, Taym Ghabra, Marwan Kailani, Obeda Khalil, Hussam Shaaban, Rafea |
author_sort | Salman, Abdelrahman |
collection | PubMed |
description | AIM: To assess the efficacy and safety of accelerated corneal cross-linking in the treatment of pediatric keratoconus. METHOD: In this retrospective case series, 29 eyes of 20 pediatric patients with keratoconus underwent accelerated corneal cross-linking. Treatment was delivered at 10 mW/cm(2) for 9 minutes with a total dose of 5.4 J/cm(2). Clinical evaluation included visual acuities and refractive and Scheimpflug corneal tomography assessments. All patients with a minimum follow-up duration of 24 months were included in the study. RESULTS: Mean ± standard deviation age was 15.41 ± 2.13 years (range: 8 to 18 years). Uncorrected distance visual acuity improved significantly from 0.56 ± 0.28 to 0.42 ± 0.29 logMAR (P=0.0003), and corrected distance visual acuity improved significantly from 0.34 ± 0.23 to 0.28 ± 0.22 logMAR (P=0.014). The mean manifest refraction spherical equivalent value was significantly reduced (−0.59 ± 0.95 D, P=0.0024). While mean flat keratometry and steep keratometry values were not significantly altered (P > 0.05 for both), the mean maximum keratometry value was significantly decreased from 56.97 ± 5.24 D preoperatively to 55.84 ± 5.37 D at 24 months postoperatively (P=0.003). Maximum keratometry had progressed by >1 D in two eyes (6.89%). Permanent corneal haze was reported in one case (3.44%). CONCLUSION: Our 24-month follow-up demonstrated that accelerated corneal cross-linking appears to halt the progression of keratoconus in pediatric patients without apparent complications. Uncorrected and corrected distance visual acuities were also improved. |
format | Online Article Text |
id | pubmed-8616643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-86166432021-11-26 Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus Salman, Abdelrahman Darwish, Taym Ghabra, Marwan Kailani, Obeda Khalil, Hussam Shaaban, Rafea J Ophthalmol Research Article AIM: To assess the efficacy and safety of accelerated corneal cross-linking in the treatment of pediatric keratoconus. METHOD: In this retrospective case series, 29 eyes of 20 pediatric patients with keratoconus underwent accelerated corneal cross-linking. Treatment was delivered at 10 mW/cm(2) for 9 minutes with a total dose of 5.4 J/cm(2). Clinical evaluation included visual acuities and refractive and Scheimpflug corneal tomography assessments. All patients with a minimum follow-up duration of 24 months were included in the study. RESULTS: Mean ± standard deviation age was 15.41 ± 2.13 years (range: 8 to 18 years). Uncorrected distance visual acuity improved significantly from 0.56 ± 0.28 to 0.42 ± 0.29 logMAR (P=0.0003), and corrected distance visual acuity improved significantly from 0.34 ± 0.23 to 0.28 ± 0.22 logMAR (P=0.014). The mean manifest refraction spherical equivalent value was significantly reduced (−0.59 ± 0.95 D, P=0.0024). While mean flat keratometry and steep keratometry values were not significantly altered (P > 0.05 for both), the mean maximum keratometry value was significantly decreased from 56.97 ± 5.24 D preoperatively to 55.84 ± 5.37 D at 24 months postoperatively (P=0.003). Maximum keratometry had progressed by >1 D in two eyes (6.89%). Permanent corneal haze was reported in one case (3.44%). CONCLUSION: Our 24-month follow-up demonstrated that accelerated corneal cross-linking appears to halt the progression of keratoconus in pediatric patients without apparent complications. Uncorrected and corrected distance visual acuities were also improved. Hindawi 2021-11-18 /pmc/articles/PMC8616643/ /pubmed/34840821 http://dx.doi.org/10.1155/2021/1851883 Text en Copyright © 2021 Abdelrahman Salman et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Salman, Abdelrahman Darwish, Taym Ghabra, Marwan Kailani, Obeda Khalil, Hussam Shaaban, Rafea Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus |
title | Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus |
title_full | Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus |
title_fullStr | Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus |
title_full_unstemmed | Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus |
title_short | Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus |
title_sort | clinical outcomes of accelerated corneal cross-linking for pediatric keratoconus |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616643/ https://www.ncbi.nlm.nih.gov/pubmed/34840821 http://dx.doi.org/10.1155/2021/1851883 |
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