Cargando…
Obesity Paradox of All-Cause Mortality in 4,133 Patients Treated with Coronary Revascularization
OBJECTIVES: The purpose of this study was to determine whether there is a dose-response relationship between body mass index (BMI) and all-cause mortality in patients after coronary revascularization. METHODS: The MIMIC-III database (version 1.4) was used as the sample population. For variables with...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616700/ https://www.ncbi.nlm.nih.gov/pubmed/34887705 http://dx.doi.org/10.1155/2021/3867735 |
_version_ | 1784604401658232832 |
---|---|
author | Li, Chengzhuo Han, Didi Xu, Fengshuo Zheng, Shuai Zhang, Luming Wang, Zichen Yang, Rui Yin, Haiyan Lyu, Jun |
author_facet | Li, Chengzhuo Han, Didi Xu, Fengshuo Zheng, Shuai Zhang, Luming Wang, Zichen Yang, Rui Yin, Haiyan Lyu, Jun |
author_sort | Li, Chengzhuo |
collection | PubMed |
description | OBJECTIVES: The purpose of this study was to determine whether there is a dose-response relationship between body mass index (BMI) and all-cause mortality in patients after coronary revascularization. METHODS: The MIMIC-III database (version 1.4) was used as the sample population. For variables with less than 10% of values missing, we used the mice package of R software for multiple imputations. Cox regression was used to determine the risk factors of all-cause mortality in patients. RCSs were used to observe the relationship between BMI and all-cause mortality. Additional subgroup and sensitivity analyses were also performed to explore whether the conclusion can be applied to specific groups. RESULTS: Both univariate and multivariate Cox models indicated that the mortality risk was lower for overweight patients than for normal-weight patients (P < 0.05). In RCS models, BMI had a U-shaped relationship with all-cause mortality of patients after coronary artery bypass grafting (CABG) (P for nonlinearity = 0.0028). There was a weak U-shaped relationship between BMI and all-cause mortality after percutaneous coronary intervention (PCI), but the nonlinear relationship between these two parameters was not significant (P for nonlinearity = 0.1756). CONCLUSIONS: The obesity paradox does exist in patients treated with CABG and PCI. RCS analysis indicated that there was a U-shaped relationship between BMI and all-cause mortality in patients after CABG. After sex stratification, the relationship between BMI and all-cause mortality in male patients who received PCI was L-shaped, while the nonlinear relationship among females was not significant. |
format | Online Article Text |
id | pubmed-8616700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-86167002021-12-08 Obesity Paradox of All-Cause Mortality in 4,133 Patients Treated with Coronary Revascularization Li, Chengzhuo Han, Didi Xu, Fengshuo Zheng, Shuai Zhang, Luming Wang, Zichen Yang, Rui Yin, Haiyan Lyu, Jun J Interv Cardiol Research Article OBJECTIVES: The purpose of this study was to determine whether there is a dose-response relationship between body mass index (BMI) and all-cause mortality in patients after coronary revascularization. METHODS: The MIMIC-III database (version 1.4) was used as the sample population. For variables with less than 10% of values missing, we used the mice package of R software for multiple imputations. Cox regression was used to determine the risk factors of all-cause mortality in patients. RCSs were used to observe the relationship between BMI and all-cause mortality. Additional subgroup and sensitivity analyses were also performed to explore whether the conclusion can be applied to specific groups. RESULTS: Both univariate and multivariate Cox models indicated that the mortality risk was lower for overweight patients than for normal-weight patients (P < 0.05). In RCS models, BMI had a U-shaped relationship with all-cause mortality of patients after coronary artery bypass grafting (CABG) (P for nonlinearity = 0.0028). There was a weak U-shaped relationship between BMI and all-cause mortality after percutaneous coronary intervention (PCI), but the nonlinear relationship between these two parameters was not significant (P for nonlinearity = 0.1756). CONCLUSIONS: The obesity paradox does exist in patients treated with CABG and PCI. RCS analysis indicated that there was a U-shaped relationship between BMI and all-cause mortality in patients after CABG. After sex stratification, the relationship between BMI and all-cause mortality in male patients who received PCI was L-shaped, while the nonlinear relationship among females was not significant. Hindawi 2021-11-18 /pmc/articles/PMC8616700/ /pubmed/34887705 http://dx.doi.org/10.1155/2021/3867735 Text en Copyright © 2021 Chengzhuo Li et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Li, Chengzhuo Han, Didi Xu, Fengshuo Zheng, Shuai Zhang, Luming Wang, Zichen Yang, Rui Yin, Haiyan Lyu, Jun Obesity Paradox of All-Cause Mortality in 4,133 Patients Treated with Coronary Revascularization |
title | Obesity Paradox of All-Cause Mortality in 4,133 Patients Treated with Coronary Revascularization |
title_full | Obesity Paradox of All-Cause Mortality in 4,133 Patients Treated with Coronary Revascularization |
title_fullStr | Obesity Paradox of All-Cause Mortality in 4,133 Patients Treated with Coronary Revascularization |
title_full_unstemmed | Obesity Paradox of All-Cause Mortality in 4,133 Patients Treated with Coronary Revascularization |
title_short | Obesity Paradox of All-Cause Mortality in 4,133 Patients Treated with Coronary Revascularization |
title_sort | obesity paradox of all-cause mortality in 4,133 patients treated with coronary revascularization |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616700/ https://www.ncbi.nlm.nih.gov/pubmed/34887705 http://dx.doi.org/10.1155/2021/3867735 |
work_keys_str_mv | AT lichengzhuo obesityparadoxofallcausemortalityin4133patientstreatedwithcoronaryrevascularization AT handidi obesityparadoxofallcausemortalityin4133patientstreatedwithcoronaryrevascularization AT xufengshuo obesityparadoxofallcausemortalityin4133patientstreatedwithcoronaryrevascularization AT zhengshuai obesityparadoxofallcausemortalityin4133patientstreatedwithcoronaryrevascularization AT zhangluming obesityparadoxofallcausemortalityin4133patientstreatedwithcoronaryrevascularization AT wangzichen obesityparadoxofallcausemortalityin4133patientstreatedwithcoronaryrevascularization AT yangrui obesityparadoxofallcausemortalityin4133patientstreatedwithcoronaryrevascularization AT yinhaiyan obesityparadoxofallcausemortalityin4133patientstreatedwithcoronaryrevascularization AT lyujun obesityparadoxofallcausemortalityin4133patientstreatedwithcoronaryrevascularization |