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COVID-19 epidemic control using short-term lockdowns for collective gain

While many efforts are currently devoted to vaccines development and administration, social distancing measures, including severe restrictions such as lockdowns, remain fundamental tools to contain the spread of COVID-19. A crucial point for any government is to understand, on the basis of the epide...

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Autores principales: Bisiacco, Mauro, Pillonetto, Gianluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616743/
https://www.ncbi.nlm.nih.gov/pubmed/34849089
http://dx.doi.org/10.1016/j.arcontrol.2021.10.017
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author Bisiacco, Mauro
Pillonetto, Gianluigi
author_facet Bisiacco, Mauro
Pillonetto, Gianluigi
author_sort Bisiacco, Mauro
collection PubMed
description While many efforts are currently devoted to vaccines development and administration, social distancing measures, including severe restrictions such as lockdowns, remain fundamental tools to contain the spread of COVID-19. A crucial point for any government is to understand, on the basis of the epidemic curve, the right temporal instant to set up a lockdown and then to remove it. Different strategies are being adopted with distinct shades of intensity. USA and Europe tend to introduce restrictions of considerable temporal length. They vary in time: a severe lockdown may be reached and then gradually relaxed. An interesting alternative is the Australian model where short and sharp responses have repeatedly tackled the virus and allowed people a return to near normalcy. After a few positive cases are detected, a lockdown is immediately set. In this paper we show that the Australian model can be generalized and given a rigorous mathematical analysis, casting strategies of the type short-term pain for collective gain in the context of sliding-mode control, an important branch of nonlinear control theory. This allows us to gain important insights regarding how to implement short-term lockdowns, obtaining a better understanding of their merits and possible limitations. Effects of vaccines administration in improving the control law’s effectiveness are also illustrated. Our model predicts the duration of the severe lockdown to be set to maintain e.g. the number of people in intensive care under a certain threshold. After tuning our strategy exploiting data collected in Italy, it turns out that COVID-19 epidemic could be e.g. controlled by alternating one or two weeks of complete lockdown with one or two months of freedom, respectively. Control strategies of this kind, where the lockdown’s duration is well circumscribed, could be important also to alleviate coronavirus impact on economy.
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spelling pubmed-86167432021-11-26 COVID-19 epidemic control using short-term lockdowns for collective gain Bisiacco, Mauro Pillonetto, Gianluigi Annu Rev Control Article While many efforts are currently devoted to vaccines development and administration, social distancing measures, including severe restrictions such as lockdowns, remain fundamental tools to contain the spread of COVID-19. A crucial point for any government is to understand, on the basis of the epidemic curve, the right temporal instant to set up a lockdown and then to remove it. Different strategies are being adopted with distinct shades of intensity. USA and Europe tend to introduce restrictions of considerable temporal length. They vary in time: a severe lockdown may be reached and then gradually relaxed. An interesting alternative is the Australian model where short and sharp responses have repeatedly tackled the virus and allowed people a return to near normalcy. After a few positive cases are detected, a lockdown is immediately set. In this paper we show that the Australian model can be generalized and given a rigorous mathematical analysis, casting strategies of the type short-term pain for collective gain in the context of sliding-mode control, an important branch of nonlinear control theory. This allows us to gain important insights regarding how to implement short-term lockdowns, obtaining a better understanding of their merits and possible limitations. Effects of vaccines administration in improving the control law’s effectiveness are also illustrated. Our model predicts the duration of the severe lockdown to be set to maintain e.g. the number of people in intensive care under a certain threshold. After tuning our strategy exploiting data collected in Italy, it turns out that COVID-19 epidemic could be e.g. controlled by alternating one or two weeks of complete lockdown with one or two months of freedom, respectively. Control strategies of this kind, where the lockdown’s duration is well circumscribed, could be important also to alleviate coronavirus impact on economy. Elsevier Ltd. 2021 2021-11-26 /pmc/articles/PMC8616743/ /pubmed/34849089 http://dx.doi.org/10.1016/j.arcontrol.2021.10.017 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Bisiacco, Mauro
Pillonetto, Gianluigi
COVID-19 epidemic control using short-term lockdowns for collective gain
title COVID-19 epidemic control using short-term lockdowns for collective gain
title_full COVID-19 epidemic control using short-term lockdowns for collective gain
title_fullStr COVID-19 epidemic control using short-term lockdowns for collective gain
title_full_unstemmed COVID-19 epidemic control using short-term lockdowns for collective gain
title_short COVID-19 epidemic control using short-term lockdowns for collective gain
title_sort covid-19 epidemic control using short-term lockdowns for collective gain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616743/
https://www.ncbi.nlm.nih.gov/pubmed/34849089
http://dx.doi.org/10.1016/j.arcontrol.2021.10.017
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