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RING-finger protein 6 promotes colorectal tumorigenesis by transcriptionally activating SF3B2

RNF6 is a RING finger protein with oncogenic potential. In this study, we established colon-specific RNF6 transgenic (tg) mice, and demonstrated that RNF6 overexpression accelerated colorectal carcinogenesis compared to wild-type littermates in a chemically induced colorectal cancer (CRC) model. To...

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Detalles Bibliográficos
Autores principales:	Xu, Hui, Wong, Chi Chun, Li, Weilin, Zhou, Yunfei, Li, Yan, Wang, Lifu, Liu, Lei, Yu, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616760/ https://www.ncbi.nlm.nih.gov/pubmed/34611311 http://dx.doi.org/10.1038/s41388-021-01872-9

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