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Gut microbiome drives individual memory variation in bumblebees

The potential of the gut microbiome as a driver of individual cognitive differences in natural populations of animals remains unexplored. Here, using metagenomic sequencing of individual bumblebee hindguts, we find a positive correlation between the abundance of Lactobacillus Firm-5 cluster and memo...

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Autores principales: Li, Li, Solvi, Cwyn, Zhang, Feng, Qi, Zhaoyang, Chittka, Lars, Zhao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616916/
https://www.ncbi.nlm.nih.gov/pubmed/34824201
http://dx.doi.org/10.1038/s41467-021-26833-4
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author Li, Li
Solvi, Cwyn
Zhang, Feng
Qi, Zhaoyang
Chittka, Lars
Zhao, Wei
author_facet Li, Li
Solvi, Cwyn
Zhang, Feng
Qi, Zhaoyang
Chittka, Lars
Zhao, Wei
author_sort Li, Li
collection PubMed
description The potential of the gut microbiome as a driver of individual cognitive differences in natural populations of animals remains unexplored. Here, using metagenomic sequencing of individual bumblebee hindguts, we find a positive correlation between the abundance of Lactobacillus Firm-5 cluster and memory retention on a visual discrimination task. Supplementation with the Firm-5 species Lactobacillus apis, but not other non-Firm-5 bacterial species, enhances bees’ memory. Untargeted metabolomics after L. apis supplementation show increased LPA (14:0) glycerophospholipid in the haemolymph. Oral administration of the LPA increases long-term memory significantly. Based on our findings and metagenomic/metabolomic analyses, we propose a molecular pathway for this gut-brain interaction. Our results provide insights into proximate and ultimate causes of cognitive differences in natural bumblebee populations.
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spelling pubmed-86169162021-12-01 Gut microbiome drives individual memory variation in bumblebees Li, Li Solvi, Cwyn Zhang, Feng Qi, Zhaoyang Chittka, Lars Zhao, Wei Nat Commun Article The potential of the gut microbiome as a driver of individual cognitive differences in natural populations of animals remains unexplored. Here, using metagenomic sequencing of individual bumblebee hindguts, we find a positive correlation between the abundance of Lactobacillus Firm-5 cluster and memory retention on a visual discrimination task. Supplementation with the Firm-5 species Lactobacillus apis, but not other non-Firm-5 bacterial species, enhances bees’ memory. Untargeted metabolomics after L. apis supplementation show increased LPA (14:0) glycerophospholipid in the haemolymph. Oral administration of the LPA increases long-term memory significantly. Based on our findings and metagenomic/metabolomic analyses, we propose a molecular pathway for this gut-brain interaction. Our results provide insights into proximate and ultimate causes of cognitive differences in natural bumblebee populations. Nature Publishing Group UK 2021-11-25 /pmc/articles/PMC8616916/ /pubmed/34824201 http://dx.doi.org/10.1038/s41467-021-26833-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Li, Li
Solvi, Cwyn
Zhang, Feng
Qi, Zhaoyang
Chittka, Lars
Zhao, Wei
Gut microbiome drives individual memory variation in bumblebees
title Gut microbiome drives individual memory variation in bumblebees
title_full Gut microbiome drives individual memory variation in bumblebees
title_fullStr Gut microbiome drives individual memory variation in bumblebees
title_full_unstemmed Gut microbiome drives individual memory variation in bumblebees
title_short Gut microbiome drives individual memory variation in bumblebees
title_sort gut microbiome drives individual memory variation in bumblebees
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616916/
https://www.ncbi.nlm.nih.gov/pubmed/34824201
http://dx.doi.org/10.1038/s41467-021-26833-4
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