NUDT2 initiates viral RNA degradation by removal of 5′-phosphates

While viral replication processes are largely understood, comparably little is known on cellular mechanisms degrading viral RNA. Some viral RNAs bear a 5′-triphosphate (PPP-) group that impairs degradation by the canonical 5′-3′ degradation pathway. Here we show that the Nudix hydrolase 2 (NUDT2) tr...

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Detalles Bibliográficos
Autores principales: Laudenbach, Beatrice T., Krey, Karsten, Emslander, Quirin, Andersen, Line Lykke, Reim, Alexander, Scaturro, Pietro, Mundigl, Sarah, Dächert, Christopher, Manske, Katrin, Moser, Markus, Ludwig, Janos, Wohlleber, Dirk, Kröger, Andrea, Binder, Marco, Pichlmair, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616924/
https://www.ncbi.nlm.nih.gov/pubmed/34824277
http://dx.doi.org/10.1038/s41467-021-27239-y

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