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Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank
Oxytocin is a neuromodulator and hormone that is typically associated with social cognition and behavior. In light of its purported effects on social cognition and behavior, research has investigated its potential as a treatment for psychiatric illnesses characterized by social dysfunction, such as...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616952/ https://www.ncbi.nlm.nih.gov/pubmed/34824196 http://dx.doi.org/10.1038/s41398-021-01725-9 |
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author | Winterton, Adriano Bettella, Francesco de Lange, Ann-Marie G. Haram, Marit Steen, Nils Eiel Westlye, Lars T. Andreassen, Ole A. Quintana, Daniel S. |
author_facet | Winterton, Adriano Bettella, Francesco de Lange, Ann-Marie G. Haram, Marit Steen, Nils Eiel Westlye, Lars T. Andreassen, Ole A. Quintana, Daniel S. |
author_sort | Winterton, Adriano |
collection | PubMed |
description | Oxytocin is a neuromodulator and hormone that is typically associated with social cognition and behavior. In light of its purported effects on social cognition and behavior, research has investigated its potential as a treatment for psychiatric illnesses characterized by social dysfunction, such as schizophrenia and bipolar disorder. While the results of these trials have been mixed, more recent evidence suggests that the oxytocin system is also linked with cardiometabolic conditions for which individuals with severe mental disorders are at a higher risk for developing. To investigate whether the oxytocin system has a pleiotropic effect on the etiology of severe mental illness and cardiometabolic conditions, we explored oxytocin’s role in the shared genetic liability of schizophrenia, bipolar disorder, type-2 diabetes, and several phenotypes linked with cardiovascular disease and type 2 diabetes risk using a polygenic pathway-specific approach. Analysis of a large sample with about 480,000 individuals (UK Biobank) revealed statistically significant associations across the range of phenotypes analyzed. By comparing these effects to those of polygenic scores calculated from 100 random gene sets, we also demonstrated the specificity of many of these significant results. Altogether, our results suggest that the shared effect of oxytocin-system dysfunction could help partially explain the co-occurrence of social and cardiometabolic dysfunction in severe mental illnesses. |
format | Online Article Text |
id | pubmed-8616952 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-86169522021-12-10 Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank Winterton, Adriano Bettella, Francesco de Lange, Ann-Marie G. Haram, Marit Steen, Nils Eiel Westlye, Lars T. Andreassen, Ole A. Quintana, Daniel S. Transl Psychiatry Article Oxytocin is a neuromodulator and hormone that is typically associated with social cognition and behavior. In light of its purported effects on social cognition and behavior, research has investigated its potential as a treatment for psychiatric illnesses characterized by social dysfunction, such as schizophrenia and bipolar disorder. While the results of these trials have been mixed, more recent evidence suggests that the oxytocin system is also linked with cardiometabolic conditions for which individuals with severe mental disorders are at a higher risk for developing. To investigate whether the oxytocin system has a pleiotropic effect on the etiology of severe mental illness and cardiometabolic conditions, we explored oxytocin’s role in the shared genetic liability of schizophrenia, bipolar disorder, type-2 diabetes, and several phenotypes linked with cardiovascular disease and type 2 diabetes risk using a polygenic pathway-specific approach. Analysis of a large sample with about 480,000 individuals (UK Biobank) revealed statistically significant associations across the range of phenotypes analyzed. By comparing these effects to those of polygenic scores calculated from 100 random gene sets, we also demonstrated the specificity of many of these significant results. Altogether, our results suggest that the shared effect of oxytocin-system dysfunction could help partially explain the co-occurrence of social and cardiometabolic dysfunction in severe mental illnesses. Nature Publishing Group UK 2021-11-25 /pmc/articles/PMC8616952/ /pubmed/34824196 http://dx.doi.org/10.1038/s41398-021-01725-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Winterton, Adriano Bettella, Francesco de Lange, Ann-Marie G. Haram, Marit Steen, Nils Eiel Westlye, Lars T. Andreassen, Ole A. Quintana, Daniel S. Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank |
title | Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank |
title_full | Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank |
title_fullStr | Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank |
title_full_unstemmed | Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank |
title_short | Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank |
title_sort | oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the uk biobank |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616952/ https://www.ncbi.nlm.nih.gov/pubmed/34824196 http://dx.doi.org/10.1038/s41398-021-01725-9 |
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