Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear encoded mitochondrial proteins

Mislocalization of the predominantly nuclear RNA/DNA binding protein, TDP-43, occurs in motor neurons of ~95% of amyotrophic lateral sclerosis (ALS) patients, but the contribution of axonal TDP-43 to this neurodegenerative disease is unclear. Here, we show TDP-43 accumulation in intra-muscular nerve...

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Detalles Bibliográficos
Autores principales: Altman, Topaz, Ionescu, Ariel, Ibraheem, Amjad, Priesmann, Dominik, Gradus-Pery, Tal, Farberov, Luba, Alexandra, Gayster, Shelestovich, Natalia, Dafinca, Ruxandra, Shomron, Noam, Rage, Florence, Talbot, Kevin, Ward, Michael E., Dori, Amir, Krüger, Marcus, Perlson, Eran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617040/
https://www.ncbi.nlm.nih.gov/pubmed/34824257
http://dx.doi.org/10.1038/s41467-021-27221-8

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