Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors

Despite their limitations, unfractionated heparin (UFH) and bivalirudin remain standard-of-care parenteral anticoagulants for percutaneous coronary intervention (PCI). We discovered novel direct thrombin inhibitors (DTIs) from tick salivary transcriptomes and optimised their pharmacologic activity....

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Detalles Bibliográficos
Autores principales: Koh, Cho Yeow, Shih, Norrapat, Yip, Christina Y. C., Li, Aaron Wei Liang, Chen, Weiming, Amran, Fathiah S., Leong, Esther Jia En, Iyer, Janaki Krishnamoorthy, Croft, Grace, Mazlan, Muhammad Ibrahim Bin, Chee, Yen-Lin, Yap, Eng-Soo, Monroe, Dougald M., Hoffman, Maureane, Becker, Richard C., de Kleijn, Dominique P. V., Verma, Vaishali, Gupta, Amita, Chaudhary, Vijay K., Richards, A. Mark, Kini, R. Manjunatha, Chan, Mark Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617063/
https://www.ncbi.nlm.nih.gov/pubmed/34824278
http://dx.doi.org/10.1038/s41467-021-27275-8

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