Hematopoiesis under telomere attrition at the single-cell resolution

The molecular mechanisms that drive hematopoietic stem cell functional decline under conditions of telomere shortening are not completely understood. In light of recent advances in single-cell technologies, we sought to redefine the transcriptional and epigenetic landscape of mouse and human hematop...

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Detalles Bibliográficos
Autores principales: Thongon, Natthakan, Ma, Feiyang, Santoni, Andrea, Marchesini, Matteo, Fiorini, Elena, Rose, Ashley, Adema, Vera, Ganan-Gomez, Irene, Groarke, Emma M., Gutierrez-Rodrigues, Fernanda, Chen, Shuaitong, Lockyer, Pamela, Schneider, Sarah, Bueso-Ramos, Carlos, Montalban-Bravo, Guillermo, Class, Caleb A., Soltysiak, Kelly A., Pellegrini, Matteo, Sahin, Ergun, Bertuch, Alison A., DiNardo, Courtney D., Garcia-Manero, Guillermo, Young, Neal S., Dwyer, Karen, Colla, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617077/
https://www.ncbi.nlm.nih.gov/pubmed/34824242
http://dx.doi.org/10.1038/s41467-021-27206-7

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