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Spike residue 403 affects binding of coronavirus spikes to human ACE2

The bat sarbecovirus RaTG13 is a close relative of SARS-CoV-2, the cause of the COVID-19 pandemic. However, this bat virus was most likely unable to directly infect humans since its Spike (S) protein does not interact efficiently with the human ACE2 receptor. Here, we show that a single T403R mutati...

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Detalles Bibliográficos
Autores principales:	Zech, Fabian, Schniertshauer, Daniel, Jung, Christoph, Herrmann, Alexandra, Cordsmeier, Arne, Xie, Qinya, Nchioua, Rayhane, Prelli Bozzo, Caterina, Volcic, Meta, Koepke, Lennart, Müller, Janis A., Krüger, Jana, Heller, Sandra, Stenger, Steffen, Hoffmann, Markus, Pöhlmann, Stefan, Kleger, Alexander, Jacob, Timo, Conzelmann, Karl-Klaus, Ensser, Armin, Sparrer, Konstantin M. J., Kirchhoff, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617078/ https://www.ncbi.nlm.nih.gov/pubmed/34824253 http://dx.doi.org/10.1038/s41467-021-27180-0

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