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Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence

Patients with Alzheimer’s disease (AD) often have osteoporosis or osteopenia. However, their direct link and relationship remain largely unclear. Previous studies have detected osteoporotic deficits in young adult Tg2576 and TgAPP(swe)(OCN) mice, which express APP(swe) (Swedish mutant) ubiquitously...

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Detalles Bibliográficos
Autores principales:	Pan, Jin-Xiu, Sun, Dong, Lee, Daehoon, Xiong, Lei, Ren, Xiao, Guo, Hao-han, Yao, Ling-Ling, Lu, Yuyi, Jung, Caroline, Xiong, Wen-Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617160/ https://www.ncbi.nlm.nih.gov/pubmed/34824365 http://dx.doi.org/10.1038/s42003-021-02843-2

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