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Wolbachia reduces virus infection in a natural population of Drosophila

Wolbachia is a maternally transmitted bacterial symbiont that is estimated to infect approximately half of arthropod species. In the laboratory it can increase the resistance of insects to viral infection, but its effect on viruses in nature is unknown. Here we report that in a natural population of...

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Autores principales: Cogni, Rodrigo, Ding, Shuai Dominique, Pimentel, André C., Day, Jonathan P., Jiggins, Francis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617179/
https://www.ncbi.nlm.nih.gov/pubmed/34824354
http://dx.doi.org/10.1038/s42003-021-02838-z
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author Cogni, Rodrigo
Ding, Shuai Dominique
Pimentel, André C.
Day, Jonathan P.
Jiggins, Francis M.
author_facet Cogni, Rodrigo
Ding, Shuai Dominique
Pimentel, André C.
Day, Jonathan P.
Jiggins, Francis M.
author_sort Cogni, Rodrigo
collection PubMed
description Wolbachia is a maternally transmitted bacterial symbiont that is estimated to infect approximately half of arthropod species. In the laboratory it can increase the resistance of insects to viral infection, but its effect on viruses in nature is unknown. Here we report that in a natural population of Drosophila melanogaster, individuals that are infected with Wolbachia are less likely to be infected by viruses. By characterising the virome by metagenomic sequencing and then testing individual flies for infection, we found the protective effect of Wolbachia was virus-specific, with the prevalence of infection being up to 15% greater in Wolbachia-free flies. The antiviral effects of Wolbachia may contribute to its extraordinary ecological success, and in nature the symbiont may be an important component of the antiviral defences of insects.
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spelling pubmed-86171792021-12-10 Wolbachia reduces virus infection in a natural population of Drosophila Cogni, Rodrigo Ding, Shuai Dominique Pimentel, André C. Day, Jonathan P. Jiggins, Francis M. Commun Biol Article Wolbachia is a maternally transmitted bacterial symbiont that is estimated to infect approximately half of arthropod species. In the laboratory it can increase the resistance of insects to viral infection, but its effect on viruses in nature is unknown. Here we report that in a natural population of Drosophila melanogaster, individuals that are infected with Wolbachia are less likely to be infected by viruses. By characterising the virome by metagenomic sequencing and then testing individual flies for infection, we found the protective effect of Wolbachia was virus-specific, with the prevalence of infection being up to 15% greater in Wolbachia-free flies. The antiviral effects of Wolbachia may contribute to its extraordinary ecological success, and in nature the symbiont may be an important component of the antiviral defences of insects. Nature Publishing Group UK 2021-11-25 /pmc/articles/PMC8617179/ /pubmed/34824354 http://dx.doi.org/10.1038/s42003-021-02838-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Cogni, Rodrigo
Ding, Shuai Dominique
Pimentel, André C.
Day, Jonathan P.
Jiggins, Francis M.
Wolbachia reduces virus infection in a natural population of Drosophila
title Wolbachia reduces virus infection in a natural population of Drosophila
title_full Wolbachia reduces virus infection in a natural population of Drosophila
title_fullStr Wolbachia reduces virus infection in a natural population of Drosophila
title_full_unstemmed Wolbachia reduces virus infection in a natural population of Drosophila
title_short Wolbachia reduces virus infection in a natural population of Drosophila
title_sort wolbachia reduces virus infection in a natural population of drosophila
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617179/
https://www.ncbi.nlm.nih.gov/pubmed/34824354
http://dx.doi.org/10.1038/s42003-021-02838-z
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