Misoprostol treatment prevents hypoxia-induced cardiac dysfunction through a 14-3-3 and PKA regulatory motif on Bnip3

Systemic hypoxia is a common element in most perinatal emergencies and is a known driver of Bnip3 expression in the neonatal heart. Bnip3 plays a prominent role in the evolution of necrotic cell death, disrupting ER calcium homeostasis and initiating mitochondrial permeability transition (MPT). Emer...

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Detalles Bibliográficos
Autores principales: Martens, Matthew D., Seshadri, Nivedita, Nguyen, Lucas, Chapman, Donald, Henson, Elizabeth S., Xiang, Bo, Falk, Landon, Mendoza, Arielys, Rattan, Sunil, Field, Jared T., Kawalec, Philip, Gibson, Spencer B., Keijzer, Richard, Saleem, Ayesha, Hatch, Grant M., Doucette, Christine A., Karch, Jason M., Dolinsky, Vernon W., Dixon, Ian M., West, Adrian R., Rampitsch, Christof, Gordon, Joseph W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617186/
https://www.ncbi.nlm.nih.gov/pubmed/34824192
http://dx.doi.org/10.1038/s41419-021-04402-3

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