Two novel human anti-CD25 antibodies with antitumor activity inversely related to their affinity and in vitro activity

High tumor regulatory T (Treg) cell infiltration is associated with poor prognosis of many cancers. CD25 is highly expressed on tumor Treg cells and is a potential target for Treg deletion. Previously characterized anti-CD25 antibodies appear to have limited efficacy in tumor inhibition. Here we ide...

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Detalles Bibliográficos
Autores principales: Song, Deyong, Liu, Xiu, Dong, Chuangchuang, Wang, Qiaoping, Sha, Chunjie, Liu, Chuan, Ning, Zhenfei, Han, Jing, Liu, Hong, Zong, Mengqi, Zhao, Yanyan, Li, Ying, Liu, Guangsheng, Shao, Xin, Dou, Changlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617198/
https://www.ncbi.nlm.nih.gov/pubmed/34824364
http://dx.doi.org/10.1038/s41598-021-02449-y

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