The JAK/STAT signaling pathway: from bench to clinic

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of va...

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Detalles Bibliográficos
Autores principales: Hu, Xiaoyi, li, Jing, Fu, Maorong, Zhao, Xia, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617206/
https://www.ncbi.nlm.nih.gov/pubmed/34824210
http://dx.doi.org/10.1038/s41392-021-00791-1
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author Hu, Xiaoyi
li, Jing
Fu, Maorong
Zhao, Xia
Wang, Wei
author_facet Hu, Xiaoyi
li, Jing
Fu, Maorong
Zhao, Xia
Wang, Wei
author_sort Hu, Xiaoyi
collection PubMed
description The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation. Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway. Moreover, we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases.
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spelling pubmed-86172062021-12-10 The JAK/STAT signaling pathway: from bench to clinic Hu, Xiaoyi li, Jing Fu, Maorong Zhao, Xia Wang, Wei Signal Transduct Target Ther Review Article The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation. Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway. Moreover, we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases. Nature Publishing Group UK 2021-11-26 /pmc/articles/PMC8617206/ /pubmed/34824210 http://dx.doi.org/10.1038/s41392-021-00791-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Hu, Xiaoyi
li, Jing
Fu, Maorong
Zhao, Xia
Wang, Wei
The JAK/STAT signaling pathway: from bench to clinic
title The JAK/STAT signaling pathway: from bench to clinic
title_full The JAK/STAT signaling pathway: from bench to clinic
title_fullStr The JAK/STAT signaling pathway: from bench to clinic
title_full_unstemmed The JAK/STAT signaling pathway: from bench to clinic
title_short The JAK/STAT signaling pathway: from bench to clinic
title_sort jak/stat signaling pathway: from bench to clinic
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617206/
https://www.ncbi.nlm.nih.gov/pubmed/34824210
http://dx.doi.org/10.1038/s41392-021-00791-1
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