Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms

Upon antibiotic stress Gram-negative pathogens deploy resistance-nodulation-cell division-type tripartite efflux pumps. These include a H(+)/drug antiporter module that recognizes structurally diverse substances, including antibiotics. Here, we show the 3.5 Å structure of subunit AdeB from the Acine...

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Detalles Bibliográficos
Autores principales: Ornik-Cha, Alina, Wilhelm, Julia, Kobylka, Jessica, Sjuts, Hanno, Vargiu, Attilio V., Malloci, Giuliano, Reitz, Julian, Seybert, Anja, Frangakis, Achilleas S., Pos, Klaas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617272/
https://www.ncbi.nlm.nih.gov/pubmed/34824229
http://dx.doi.org/10.1038/s41467-021-27146-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617272/
https://www.ncbi.nlm.nih.gov/pubmed/34824229
http://dx.doi.org/10.1038/s41467-021-27146-2

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