Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses

COVID-19 manifests as a milder disease in children than adults, but the underlying mechanisms are not fully characterized. Here we assess the difference in cellular or humoral immune responses of pediatric and adult COVID-19 patients to see if these factors contribute to the severity dichotomy. Chil...

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Detalles Bibliográficos
Autores principales: Fazolo, Tiago, Lima, Karina, Fontoura, Julia C., de Souza, Priscila Oliveira, Hilario, Gabriel, Zorzetto, Renata, Júnior, Luiz Rodrigues, Pscheidt, Veridiane Maria, de Castilhos Ferreira Neto, Jayme, Haubert, Alisson F., Gambin, Izza, Oliveira, Aline C., Mello, Raissa S., de Bastos Balbe e Gutierres, Matheus, Gassen, Rodrigo Benedetti, Coimbra, Lais Durço, Borin, Alexandre, Marques, Rafael Elias, Sartor, Ivaine Tais Sauthier, Zavaglia, Gabriela Oliveira, Fernandes, Ingrid Rodrigues, Nakaya, Helder I., Varela, Fernanda Hammes, Polese-Bonatto, Márcia, Borges, Thiago J., Callegari-Jacques, Sidia Maria, da Costa, Marcela Santos Correa, de Araujo Schwartz, Jaqueline, Scotta, Marcelo Comerlato, Stein, Renato T., Bonorino, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617275/
https://www.ncbi.nlm.nih.gov/pubmed/34824230
http://dx.doi.org/10.1038/s41467-021-27120-y
Descripción
Sumario:COVID-19 manifests as a milder disease in children than adults, but the underlying mechanisms are not fully characterized. Here we assess the difference in cellular or humoral immune responses of pediatric and adult COVID-19 patients to see if these factors contribute to the severity dichotomy. Children’s non-specific immune profile is dominated by naive lymphocytes and HLA-DR(high)CX3CR1(low) dendritic cells; meanwhile, children show strong specific antibody and T cell responses for viral structural proteins, with their T cell responses differing from adults by having weaker CD8(+)TNF(+) T cells responses to S peptide pool but stronger responses to N and M peptide pools. Finally, viral mRNA is more abundant in pediatric patients. Our data thus support a scenario in which SARS-CoV-2 infected children contribute to transmission yet are less susceptible to COVID-19 symptoms due to strong and differential responses to the virus.

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