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The role of prefrontal cortex in cognitive control and executive function
Concepts of cognitive control (CC) and executive function (EF) are defined in terms of their relationships with goal-directed behavior versus habits and controlled versus automatic processing, and related to the functions of the prefrontal cortex (PFC) and related regions and networks. A psychometri...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617292/ https://www.ncbi.nlm.nih.gov/pubmed/34408280 http://dx.doi.org/10.1038/s41386-021-01132-0 |
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author | Friedman, Naomi P. Robbins, Trevor W. |
author_facet | Friedman, Naomi P. Robbins, Trevor W. |
author_sort | Friedman, Naomi P. |
collection | PubMed |
description | Concepts of cognitive control (CC) and executive function (EF) are defined in terms of their relationships with goal-directed behavior versus habits and controlled versus automatic processing, and related to the functions of the prefrontal cortex (PFC) and related regions and networks. A psychometric approach shows unity and diversity in CC constructs, with 3 components in the most commonly studied constructs: general or common CC and components specific to mental set shifting and working memory updating. These constructs are considered against the cellular and systems neurobiology of PFC and what is known of its functional neuroanatomical or network organization based on lesioning, neurochemical, and neuroimaging approaches across species. CC is also considered in the context of motivation, as “cool” and “hot” forms. Its Common CC component is shown to be distinct from general intelligence (g) and closely related to response inhibition. Impairments in CC are considered as possible causes of psychiatric symptoms and consequences of disorders. The relationships of CC with the general factor of psychopathology (p) and dimensional constructs such as impulsivity in large scale developmental and adult populations are considered, as well as implications for genetic studies and RDoC approaches to psychiatric classification. |
format | Online Article Text |
id | pubmed-8617292 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-86172922021-12-10 The role of prefrontal cortex in cognitive control and executive function Friedman, Naomi P. Robbins, Trevor W. Neuropsychopharmacology Review Article Concepts of cognitive control (CC) and executive function (EF) are defined in terms of their relationships with goal-directed behavior versus habits and controlled versus automatic processing, and related to the functions of the prefrontal cortex (PFC) and related regions and networks. A psychometric approach shows unity and diversity in CC constructs, with 3 components in the most commonly studied constructs: general or common CC and components specific to mental set shifting and working memory updating. These constructs are considered against the cellular and systems neurobiology of PFC and what is known of its functional neuroanatomical or network organization based on lesioning, neurochemical, and neuroimaging approaches across species. CC is also considered in the context of motivation, as “cool” and “hot” forms. Its Common CC component is shown to be distinct from general intelligence (g) and closely related to response inhibition. Impairments in CC are considered as possible causes of psychiatric symptoms and consequences of disorders. The relationships of CC with the general factor of psychopathology (p) and dimensional constructs such as impulsivity in large scale developmental and adult populations are considered, as well as implications for genetic studies and RDoC approaches to psychiatric classification. Springer International Publishing 2021-08-18 2022-01 /pmc/articles/PMC8617292/ /pubmed/34408280 http://dx.doi.org/10.1038/s41386-021-01132-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Friedman, Naomi P. Robbins, Trevor W. The role of prefrontal cortex in cognitive control and executive function |
title | The role of prefrontal cortex in cognitive control and executive function |
title_full | The role of prefrontal cortex in cognitive control and executive function |
title_fullStr | The role of prefrontal cortex in cognitive control and executive function |
title_full_unstemmed | The role of prefrontal cortex in cognitive control and executive function |
title_short | The role of prefrontal cortex in cognitive control and executive function |
title_sort | role of prefrontal cortex in cognitive control and executive function |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617292/ https://www.ncbi.nlm.nih.gov/pubmed/34408280 http://dx.doi.org/10.1038/s41386-021-01132-0 |
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