Opening of a cryptic pocket in β-lactamase increases penicillinase activity

Understanding the functional role of protein-excited states has important implications in protein design and drug discovery. However, because these states are difficult to find and study, it is still unclear if excited states simply result from thermal fluctuations and generally detract from functio...

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Detalles Bibliográficos
Autores principales: Knoverek, Catherine R., Mallimadugula, Upasana L., Singh, Sukrit, Rennella, Enrico, Frederick, Thomas E., Yuwen, Tairan, Raavicharla, Shreya, Kay, Lewis E., Bowman, Gregory R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617505/
https://www.ncbi.nlm.nih.gov/pubmed/34799442
http://dx.doi.org/10.1073/pnas.2106473118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617505/
https://www.ncbi.nlm.nih.gov/pubmed/34799442
http://dx.doi.org/10.1073/pnas.2106473118

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