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Opening of a cryptic pocket in β-lactamase increases penicillinase activity
Understanding the functional role of protein-excited states has important implications in protein design and drug discovery. However, because these states are difficult to find and study, it is still unclear if excited states simply result from thermal fluctuations and generally detract from functio...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617505/ https://www.ncbi.nlm.nih.gov/pubmed/34799442 http://dx.doi.org/10.1073/pnas.2106473118 |