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The innate immune system in human kidney inflammaging

Elderly individuals with chronic disorders tend to develop inflammaging, a condition associated with elevated levels of blood inflammatory markers, and increased susceptibility to chronic disease progression. Native and adaptive immunity are both involved in immune system senescence, kidney fibrosis...

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Detalles Bibliográficos
Autores principales: Sepe, Vincenzo, Libetta, Carmelo, Gregorini, Marilena, Rampino, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617550/
https://www.ncbi.nlm.nih.gov/pubmed/34826123
http://dx.doi.org/10.1007/s40620-021-01153-4
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author Sepe, Vincenzo
Libetta, Carmelo
Gregorini, Marilena
Rampino, Teresa
author_facet Sepe, Vincenzo
Libetta, Carmelo
Gregorini, Marilena
Rampino, Teresa
author_sort Sepe, Vincenzo
collection PubMed
description Elderly individuals with chronic disorders tend to develop inflammaging, a condition associated with elevated levels of blood inflammatory markers, and increased susceptibility to chronic disease progression. Native and adaptive immunity are both involved in immune system senescence, kidney fibrosis and aging. The innate immune system is characterized by a limited number of receptors, constantly challenged by self and non-self stimuli. Circulating and kidney resident myeloid and lymphoid cells are all equipped with pattern recognition receptors (PRRs). Recent reports on PRRs show kidney overexpression of toll-like receptors (TLRs) in inflammaging autoimmune renal diseases, vasculitis, acute kidney injury and kidney transplant rejection. TLR upregulation leads to proinflammatory cytokine induction, fibrosis, and chronic kidney disease progression. TLR2 blockade in a murine model of renal ischemia reperfusion injury prevented the escape of natural killer cells and neutrophils by inflammaging kidney injury. Tumor necrosis factor-α blockade in endothelial cells with senescence-associated secretory phenotype significantly reduced interleukin-6 release. These findings should encourage experimental and translational clinical trials aimed at modulating renal inflammaging by native immunity blockade.
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spelling pubmed-86175502021-11-26 The innate immune system in human kidney inflammaging Sepe, Vincenzo Libetta, Carmelo Gregorini, Marilena Rampino, Teresa J Nephrol Review Elderly individuals with chronic disorders tend to develop inflammaging, a condition associated with elevated levels of blood inflammatory markers, and increased susceptibility to chronic disease progression. Native and adaptive immunity are both involved in immune system senescence, kidney fibrosis and aging. The innate immune system is characterized by a limited number of receptors, constantly challenged by self and non-self stimuli. Circulating and kidney resident myeloid and lymphoid cells are all equipped with pattern recognition receptors (PRRs). Recent reports on PRRs show kidney overexpression of toll-like receptors (TLRs) in inflammaging autoimmune renal diseases, vasculitis, acute kidney injury and kidney transplant rejection. TLR upregulation leads to proinflammatory cytokine induction, fibrosis, and chronic kidney disease progression. TLR2 blockade in a murine model of renal ischemia reperfusion injury prevented the escape of natural killer cells and neutrophils by inflammaging kidney injury. Tumor necrosis factor-α blockade in endothelial cells with senescence-associated secretory phenotype significantly reduced interleukin-6 release. These findings should encourage experimental and translational clinical trials aimed at modulating renal inflammaging by native immunity blockade. Springer International Publishing 2021-11-26 2022 /pmc/articles/PMC8617550/ /pubmed/34826123 http://dx.doi.org/10.1007/s40620-021-01153-4 Text en © Italian Society of Nephrology 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Sepe, Vincenzo
Libetta, Carmelo
Gregorini, Marilena
Rampino, Teresa
The innate immune system in human kidney inflammaging
title The innate immune system in human kidney inflammaging
title_full The innate immune system in human kidney inflammaging
title_fullStr The innate immune system in human kidney inflammaging
title_full_unstemmed The innate immune system in human kidney inflammaging
title_short The innate immune system in human kidney inflammaging
title_sort innate immune system in human kidney inflammaging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617550/
https://www.ncbi.nlm.nih.gov/pubmed/34826123
http://dx.doi.org/10.1007/s40620-021-01153-4
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