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The innate immune system in human kidney inflammaging
Elderly individuals with chronic disorders tend to develop inflammaging, a condition associated with elevated levels of blood inflammatory markers, and increased susceptibility to chronic disease progression. Native and adaptive immunity are both involved in immune system senescence, kidney fibrosis...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617550/ https://www.ncbi.nlm.nih.gov/pubmed/34826123 http://dx.doi.org/10.1007/s40620-021-01153-4 |
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author | Sepe, Vincenzo Libetta, Carmelo Gregorini, Marilena Rampino, Teresa |
author_facet | Sepe, Vincenzo Libetta, Carmelo Gregorini, Marilena Rampino, Teresa |
author_sort | Sepe, Vincenzo |
collection | PubMed |
description | Elderly individuals with chronic disorders tend to develop inflammaging, a condition associated with elevated levels of blood inflammatory markers, and increased susceptibility to chronic disease progression. Native and adaptive immunity are both involved in immune system senescence, kidney fibrosis and aging. The innate immune system is characterized by a limited number of receptors, constantly challenged by self and non-self stimuli. Circulating and kidney resident myeloid and lymphoid cells are all equipped with pattern recognition receptors (PRRs). Recent reports on PRRs show kidney overexpression of toll-like receptors (TLRs) in inflammaging autoimmune renal diseases, vasculitis, acute kidney injury and kidney transplant rejection. TLR upregulation leads to proinflammatory cytokine induction, fibrosis, and chronic kidney disease progression. TLR2 blockade in a murine model of renal ischemia reperfusion injury prevented the escape of natural killer cells and neutrophils by inflammaging kidney injury. Tumor necrosis factor-α blockade in endothelial cells with senescence-associated secretory phenotype significantly reduced interleukin-6 release. These findings should encourage experimental and translational clinical trials aimed at modulating renal inflammaging by native immunity blockade. |
format | Online Article Text |
id | pubmed-8617550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-86175502021-11-26 The innate immune system in human kidney inflammaging Sepe, Vincenzo Libetta, Carmelo Gregorini, Marilena Rampino, Teresa J Nephrol Review Elderly individuals with chronic disorders tend to develop inflammaging, a condition associated with elevated levels of blood inflammatory markers, and increased susceptibility to chronic disease progression. Native and adaptive immunity are both involved in immune system senescence, kidney fibrosis and aging. The innate immune system is characterized by a limited number of receptors, constantly challenged by self and non-self stimuli. Circulating and kidney resident myeloid and lymphoid cells are all equipped with pattern recognition receptors (PRRs). Recent reports on PRRs show kidney overexpression of toll-like receptors (TLRs) in inflammaging autoimmune renal diseases, vasculitis, acute kidney injury and kidney transplant rejection. TLR upregulation leads to proinflammatory cytokine induction, fibrosis, and chronic kidney disease progression. TLR2 blockade in a murine model of renal ischemia reperfusion injury prevented the escape of natural killer cells and neutrophils by inflammaging kidney injury. Tumor necrosis factor-α blockade in endothelial cells with senescence-associated secretory phenotype significantly reduced interleukin-6 release. These findings should encourage experimental and translational clinical trials aimed at modulating renal inflammaging by native immunity blockade. Springer International Publishing 2021-11-26 2022 /pmc/articles/PMC8617550/ /pubmed/34826123 http://dx.doi.org/10.1007/s40620-021-01153-4 Text en © Italian Society of Nephrology 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Sepe, Vincenzo Libetta, Carmelo Gregorini, Marilena Rampino, Teresa The innate immune system in human kidney inflammaging |
title | The innate immune system in human kidney inflammaging |
title_full | The innate immune system in human kidney inflammaging |
title_fullStr | The innate immune system in human kidney inflammaging |
title_full_unstemmed | The innate immune system in human kidney inflammaging |
title_short | The innate immune system in human kidney inflammaging |
title_sort | innate immune system in human kidney inflammaging |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617550/ https://www.ncbi.nlm.nih.gov/pubmed/34826123 http://dx.doi.org/10.1007/s40620-021-01153-4 |
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