Direct Interstitial Decongestion in an Animal Model of Acute-on-Chronic Ischemic Heart Failure

Removal of excess fluid in acute decompensated heart failure (ADHF) targets the intravascular space, whereas most fluid resides in the interstitial space. The authors evaluated an approach to interstitial decongestion using a device to enhance lymph flow. The device was deployed in sheep with induce...

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Autores principales: Abraham, William T., Jonas, Michael, Dongaonkar, Ranjeet M., Geist, Beth, Ueyama, Yukie, Render, Kevin, Youngblood, Brad, Muir, William, Hamlin, Robert, del Rio, Carlos L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617571/
https://www.ncbi.nlm.nih.gov/pubmed/34869951
http://dx.doi.org/10.1016/j.jacbts.2021.09.008
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author Abraham, William T.
Jonas, Michael
Dongaonkar, Ranjeet M.
Geist, Beth
Ueyama, Yukie
Render, Kevin
Youngblood, Brad
Muir, William
Hamlin, Robert
del Rio, Carlos L.
author_facet Abraham, William T.
Jonas, Michael
Dongaonkar, Ranjeet M.
Geist, Beth
Ueyama, Yukie
Render, Kevin
Youngblood, Brad
Muir, William
Hamlin, Robert
del Rio, Carlos L.
author_sort Abraham, William T.
collection PubMed
description Removal of excess fluid in acute decompensated heart failure (ADHF) targets the intravascular space, whereas most fluid resides in the interstitial space. The authors evaluated an approach to interstitial decongestion using a device to enhance lymph flow. The device was deployed in sheep with induced heart failure (HF) and acute volume overload to create a low-pressure zone at the thoracic duct outlet. Treatment decreased extravascular lung water (EVLW) volume (mL/kg) (-32% ± 9%, P = 0.029) compared to controls (+46% ± 9%, P = 0.003). Device-mediated thoracic duct decompression effectively reduced EVLW. Human studies may establish device-based interstitial decongestion as a new ADHF treatment.
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spelling pubmed-86175712021-12-02 Direct Interstitial Decongestion in an Animal Model of Acute-on-Chronic Ischemic Heart Failure Abraham, William T. Jonas, Michael Dongaonkar, Ranjeet M. Geist, Beth Ueyama, Yukie Render, Kevin Youngblood, Brad Muir, William Hamlin, Robert del Rio, Carlos L. JACC Basic Transl Sci Preclinical Research Removal of excess fluid in acute decompensated heart failure (ADHF) targets the intravascular space, whereas most fluid resides in the interstitial space. The authors evaluated an approach to interstitial decongestion using a device to enhance lymph flow. The device was deployed in sheep with induced heart failure (HF) and acute volume overload to create a low-pressure zone at the thoracic duct outlet. Treatment decreased extravascular lung water (EVLW) volume (mL/kg) (-32% ± 9%, P = 0.029) compared to controls (+46% ± 9%, P = 0.003). Device-mediated thoracic duct decompression effectively reduced EVLW. Human studies may establish device-based interstitial decongestion as a new ADHF treatment. Elsevier 2021-11-22 /pmc/articles/PMC8617571/ /pubmed/34869951 http://dx.doi.org/10.1016/j.jacbts.2021.09.008 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Preclinical Research
Abraham, William T.
Jonas, Michael
Dongaonkar, Ranjeet M.
Geist, Beth
Ueyama, Yukie
Render, Kevin
Youngblood, Brad
Muir, William
Hamlin, Robert
del Rio, Carlos L.
Direct Interstitial Decongestion in an Animal Model of Acute-on-Chronic Ischemic Heart Failure
title Direct Interstitial Decongestion in an Animal Model of Acute-on-Chronic Ischemic Heart Failure
title_full Direct Interstitial Decongestion in an Animal Model of Acute-on-Chronic Ischemic Heart Failure
title_fullStr Direct Interstitial Decongestion in an Animal Model of Acute-on-Chronic Ischemic Heart Failure
title_full_unstemmed Direct Interstitial Decongestion in an Animal Model of Acute-on-Chronic Ischemic Heart Failure
title_short Direct Interstitial Decongestion in an Animal Model of Acute-on-Chronic Ischemic Heart Failure
title_sort direct interstitial decongestion in an animal model of acute-on-chronic ischemic heart failure
topic Preclinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617571/
https://www.ncbi.nlm.nih.gov/pubmed/34869951
http://dx.doi.org/10.1016/j.jacbts.2021.09.008
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