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Association between Serum Lipid Parameters and Cognitive Performance in Older Adults
(1) Background: Previous studies have suggested the association between lipid profiles and cognitive function in older adults. However, they generated inconsistent results. We aim to determine the relationship between lipid profiles and cognitive performance in older adults. (2) Methods: We used the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617666/ https://www.ncbi.nlm.nih.gov/pubmed/34830687 http://dx.doi.org/10.3390/jcm10225405 |
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author | Lee, Jaeho Lee, Sohyae Min, Jin-young Min, Kyoung-bok |
author_facet | Lee, Jaeho Lee, Sohyae Min, Jin-young Min, Kyoung-bok |
author_sort | Lee, Jaeho |
collection | PubMed |
description | (1) Background: Previous studies have suggested the association between lipid profiles and cognitive function in older adults. However, they generated inconsistent results. We aim to determine the relationship between lipid profiles and cognitive performance in older adults. (2) Methods: We used the 2011–2014 National Health and Nutrition Examination Survey. This study included 2215 participants who were aged more than 60 years old and free of coronary heart disease or stroke. Lipid profiles included total cholesterol (TC), low density lipid cholesterol (LDL), high density lipid cholesterol (HDL), and triglyceride (TG). Cognitive function was assessed using the digit symbol substitution test (DSST). (3) Results: Positive correlations of DSST were observed with TC (r = 0.111; p < 0.0001), HDL (r = 0.127; p < 0.0001), and LDL (r = 0.107; p = 0.0005). However, there was no significant relationship between TG and DSST. A one-unit increase in HDL was associated with an increase in DSST score (beta coefficient: 0.036; p = 0.018); but the association was not significant for LDL, TG, and TC. In the categorical analysis, the high HDL group had a higher DSST score than the low HDL group (beta = 3.113; p < 0.0001) and the low TG group was more likely to show a lower DSST score than the high TC group (beta = −1.837; p = 0.0461). However, LDL and TC showed no statistically significant associations. Moreover, HDL was only associated with a 0.701 times increased risk of cognitive impairment (95% CI = 0.523–0.938) in the logistic regression analysis. (4) Conclusions: Higher blood concentrations of HDL levels were positively associated with DSST scores in older adults. We suggest that the high levels of HDL may be a protective factor against cognitive impairment. |
format | Online Article Text |
id | pubmed-8617666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86176662021-11-27 Association between Serum Lipid Parameters and Cognitive Performance in Older Adults Lee, Jaeho Lee, Sohyae Min, Jin-young Min, Kyoung-bok J Clin Med Article (1) Background: Previous studies have suggested the association between lipid profiles and cognitive function in older adults. However, they generated inconsistent results. We aim to determine the relationship between lipid profiles and cognitive performance in older adults. (2) Methods: We used the 2011–2014 National Health and Nutrition Examination Survey. This study included 2215 participants who were aged more than 60 years old and free of coronary heart disease or stroke. Lipid profiles included total cholesterol (TC), low density lipid cholesterol (LDL), high density lipid cholesterol (HDL), and triglyceride (TG). Cognitive function was assessed using the digit symbol substitution test (DSST). (3) Results: Positive correlations of DSST were observed with TC (r = 0.111; p < 0.0001), HDL (r = 0.127; p < 0.0001), and LDL (r = 0.107; p = 0.0005). However, there was no significant relationship between TG and DSST. A one-unit increase in HDL was associated with an increase in DSST score (beta coefficient: 0.036; p = 0.018); but the association was not significant for LDL, TG, and TC. In the categorical analysis, the high HDL group had a higher DSST score than the low HDL group (beta = 3.113; p < 0.0001) and the low TG group was more likely to show a lower DSST score than the high TC group (beta = −1.837; p = 0.0461). However, LDL and TC showed no statistically significant associations. Moreover, HDL was only associated with a 0.701 times increased risk of cognitive impairment (95% CI = 0.523–0.938) in the logistic regression analysis. (4) Conclusions: Higher blood concentrations of HDL levels were positively associated with DSST scores in older adults. We suggest that the high levels of HDL may be a protective factor against cognitive impairment. MDPI 2021-11-19 /pmc/articles/PMC8617666/ /pubmed/34830687 http://dx.doi.org/10.3390/jcm10225405 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Jaeho Lee, Sohyae Min, Jin-young Min, Kyoung-bok Association between Serum Lipid Parameters and Cognitive Performance in Older Adults |
title | Association between Serum Lipid Parameters and Cognitive Performance in Older Adults |
title_full | Association between Serum Lipid Parameters and Cognitive Performance in Older Adults |
title_fullStr | Association between Serum Lipid Parameters and Cognitive Performance in Older Adults |
title_full_unstemmed | Association between Serum Lipid Parameters and Cognitive Performance in Older Adults |
title_short | Association between Serum Lipid Parameters and Cognitive Performance in Older Adults |
title_sort | association between serum lipid parameters and cognitive performance in older adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617666/ https://www.ncbi.nlm.nih.gov/pubmed/34830687 http://dx.doi.org/10.3390/jcm10225405 |
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