Cargando…
Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV
Background: Pulmonary hypertension (PH) is a rare progressive and lethal disease affecting pulmonary arteries and heart function. The disease may compromise the nutritional status of the patient, which impairs their physical performance. This study aimed to determine the prevalence of micronutrient...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617670/ https://www.ncbi.nlm.nih.gov/pubmed/34836178 http://dx.doi.org/10.3390/nu13113923 |
_version_ | 1784604561346920448 |
---|---|
author | Vinke, Paulien Koudstaal, Thomas Muskens, Femke van den Bosch, Annemien Balvers, Michiel Poland, Mieke Witkamp, Renger F. van Norren, Klaske Boomars, Karin A. |
author_facet | Vinke, Paulien Koudstaal, Thomas Muskens, Femke van den Bosch, Annemien Balvers, Michiel Poland, Mieke Witkamp, Renger F. van Norren, Klaske Boomars, Karin A. |
author_sort | Vinke, Paulien |
collection | PubMed |
description | Background: Pulmonary hypertension (PH) is a rare progressive and lethal disease affecting pulmonary arteries and heart function. The disease may compromise the nutritional status of the patient, which impairs their physical performance. This study aimed to determine the prevalence of micronutrient deficiencies in pulmonary arterial hypertension (PAH) and chronic thrombo-embolic pulmonary hypertension (CTEPH) patients. Methods: Eighty-one blood samples from a prospective observational cohort study were analyzed for concentrations of micronutrients and inflammation-related factors. The samples consisted of newly diagnosed (treatment-naive) PAH and CTEPH patients and patients treated for 1.5 years according to ERS/ESC guidelines. Results: In the newly diagnosed group, 42% of PAH patients and 21% of CTEPH patients were iron deficient compared to 29% of PAH patients and 20% of CTEPH patients in the treatment group. Vitamin D deficiency occurred in 42% of the newly diagnosed PAH patients, 71% of the newly diagnosed CTEPH patients, 68% of the treated PAH patients, and 70% of the treated CTEPH patients. Iron levels correlated with the 6 min walking distance (6MWD). Conclusions: Iron and vitamin D deficiencies are highly prevalent in PAH and CTEPH patients, underlining the need for monitoring their status. Studies evaluating the effects of supplementation strategies for iron and vitamin D are necessary. |
format | Online Article Text |
id | pubmed-8617670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86176702021-11-27 Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV Vinke, Paulien Koudstaal, Thomas Muskens, Femke van den Bosch, Annemien Balvers, Michiel Poland, Mieke Witkamp, Renger F. van Norren, Klaske Boomars, Karin A. Nutrients Article Background: Pulmonary hypertension (PH) is a rare progressive and lethal disease affecting pulmonary arteries and heart function. The disease may compromise the nutritional status of the patient, which impairs their physical performance. This study aimed to determine the prevalence of micronutrient deficiencies in pulmonary arterial hypertension (PAH) and chronic thrombo-embolic pulmonary hypertension (CTEPH) patients. Methods: Eighty-one blood samples from a prospective observational cohort study were analyzed for concentrations of micronutrients and inflammation-related factors. The samples consisted of newly diagnosed (treatment-naive) PAH and CTEPH patients and patients treated for 1.5 years according to ERS/ESC guidelines. Results: In the newly diagnosed group, 42% of PAH patients and 21% of CTEPH patients were iron deficient compared to 29% of PAH patients and 20% of CTEPH patients in the treatment group. Vitamin D deficiency occurred in 42% of the newly diagnosed PAH patients, 71% of the newly diagnosed CTEPH patients, 68% of the treated PAH patients, and 70% of the treated CTEPH patients. Iron levels correlated with the 6 min walking distance (6MWD). Conclusions: Iron and vitamin D deficiencies are highly prevalent in PAH and CTEPH patients, underlining the need for monitoring their status. Studies evaluating the effects of supplementation strategies for iron and vitamin D are necessary. MDPI 2021-11-01 /pmc/articles/PMC8617670/ /pubmed/34836178 http://dx.doi.org/10.3390/nu13113923 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vinke, Paulien Koudstaal, Thomas Muskens, Femke van den Bosch, Annemien Balvers, Michiel Poland, Mieke Witkamp, Renger F. van Norren, Klaske Boomars, Karin A. Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV |
title | Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV |
title_full | Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV |
title_fullStr | Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV |
title_full_unstemmed | Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV |
title_short | Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV |
title_sort | prevalence of micronutrient deficiencies and relationship with clinical and patient-related outcomes in pulmonary hypertension types i and iv |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617670/ https://www.ncbi.nlm.nih.gov/pubmed/34836178 http://dx.doi.org/10.3390/nu13113923 |
work_keys_str_mv | AT vinkepaulien prevalenceofmicronutrientdeficienciesandrelationshipwithclinicalandpatientrelatedoutcomesinpulmonaryhypertensiontypesiandiv AT koudstaalthomas prevalenceofmicronutrientdeficienciesandrelationshipwithclinicalandpatientrelatedoutcomesinpulmonaryhypertensiontypesiandiv AT muskensfemke prevalenceofmicronutrientdeficienciesandrelationshipwithclinicalandpatientrelatedoutcomesinpulmonaryhypertensiontypesiandiv AT vandenboschannemien prevalenceofmicronutrientdeficienciesandrelationshipwithclinicalandpatientrelatedoutcomesinpulmonaryhypertensiontypesiandiv AT balversmichiel prevalenceofmicronutrientdeficienciesandrelationshipwithclinicalandpatientrelatedoutcomesinpulmonaryhypertensiontypesiandiv AT polandmieke prevalenceofmicronutrientdeficienciesandrelationshipwithclinicalandpatientrelatedoutcomesinpulmonaryhypertensiontypesiandiv AT witkamprengerf prevalenceofmicronutrientdeficienciesandrelationshipwithclinicalandpatientrelatedoutcomesinpulmonaryhypertensiontypesiandiv AT vannorrenklaske prevalenceofmicronutrientdeficienciesandrelationshipwithclinicalandpatientrelatedoutcomesinpulmonaryhypertensiontypesiandiv AT boomarskarina prevalenceofmicronutrientdeficienciesandrelationshipwithclinicalandpatientrelatedoutcomesinpulmonaryhypertensiontypesiandiv |