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Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV

Background: Pulmonary hypertension (PH) is a rare progressive and lethal disease affecting pulmonary arteries and heart function. The disease may compromise the nutritional status of the patient, which impairs their physical performance. This study aimed to determine the prevalence of micronutrient...

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Autores principales: Vinke, Paulien, Koudstaal, Thomas, Muskens, Femke, van den Bosch, Annemien, Balvers, Michiel, Poland, Mieke, Witkamp, Renger F., van Norren, Klaske, Boomars, Karin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617670/
https://www.ncbi.nlm.nih.gov/pubmed/34836178
http://dx.doi.org/10.3390/nu13113923
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author Vinke, Paulien
Koudstaal, Thomas
Muskens, Femke
van den Bosch, Annemien
Balvers, Michiel
Poland, Mieke
Witkamp, Renger F.
van Norren, Klaske
Boomars, Karin A.
author_facet Vinke, Paulien
Koudstaal, Thomas
Muskens, Femke
van den Bosch, Annemien
Balvers, Michiel
Poland, Mieke
Witkamp, Renger F.
van Norren, Klaske
Boomars, Karin A.
author_sort Vinke, Paulien
collection PubMed
description Background: Pulmonary hypertension (PH) is a rare progressive and lethal disease affecting pulmonary arteries and heart function. The disease may compromise the nutritional status of the patient, which impairs their physical performance. This study aimed to determine the prevalence of micronutrient deficiencies in pulmonary arterial hypertension (PAH) and chronic thrombo-embolic pulmonary hypertension (CTEPH) patients. Methods: Eighty-one blood samples from a prospective observational cohort study were analyzed for concentrations of micronutrients and inflammation-related factors. The samples consisted of newly diagnosed (treatment-naive) PAH and CTEPH patients and patients treated for 1.5 years according to ERS/ESC guidelines. Results: In the newly diagnosed group, 42% of PAH patients and 21% of CTEPH patients were iron deficient compared to 29% of PAH patients and 20% of CTEPH patients in the treatment group. Vitamin D deficiency occurred in 42% of the newly diagnosed PAH patients, 71% of the newly diagnosed CTEPH patients, 68% of the treated PAH patients, and 70% of the treated CTEPH patients. Iron levels correlated with the 6 min walking distance (6MWD). Conclusions: Iron and vitamin D deficiencies are highly prevalent in PAH and CTEPH patients, underlining the need for monitoring their status. Studies evaluating the effects of supplementation strategies for iron and vitamin D are necessary.
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spelling pubmed-86176702021-11-27 Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV Vinke, Paulien Koudstaal, Thomas Muskens, Femke van den Bosch, Annemien Balvers, Michiel Poland, Mieke Witkamp, Renger F. van Norren, Klaske Boomars, Karin A. Nutrients Article Background: Pulmonary hypertension (PH) is a rare progressive and lethal disease affecting pulmonary arteries and heart function. The disease may compromise the nutritional status of the patient, which impairs their physical performance. This study aimed to determine the prevalence of micronutrient deficiencies in pulmonary arterial hypertension (PAH) and chronic thrombo-embolic pulmonary hypertension (CTEPH) patients. Methods: Eighty-one blood samples from a prospective observational cohort study were analyzed for concentrations of micronutrients and inflammation-related factors. The samples consisted of newly diagnosed (treatment-naive) PAH and CTEPH patients and patients treated for 1.5 years according to ERS/ESC guidelines. Results: In the newly diagnosed group, 42% of PAH patients and 21% of CTEPH patients were iron deficient compared to 29% of PAH patients and 20% of CTEPH patients in the treatment group. Vitamin D deficiency occurred in 42% of the newly diagnosed PAH patients, 71% of the newly diagnosed CTEPH patients, 68% of the treated PAH patients, and 70% of the treated CTEPH patients. Iron levels correlated with the 6 min walking distance (6MWD). Conclusions: Iron and vitamin D deficiencies are highly prevalent in PAH and CTEPH patients, underlining the need for monitoring their status. Studies evaluating the effects of supplementation strategies for iron and vitamin D are necessary. MDPI 2021-11-01 /pmc/articles/PMC8617670/ /pubmed/34836178 http://dx.doi.org/10.3390/nu13113923 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vinke, Paulien
Koudstaal, Thomas
Muskens, Femke
van den Bosch, Annemien
Balvers, Michiel
Poland, Mieke
Witkamp, Renger F.
van Norren, Klaske
Boomars, Karin A.
Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV
title Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV
title_full Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV
title_fullStr Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV
title_full_unstemmed Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV
title_short Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV
title_sort prevalence of micronutrient deficiencies and relationship with clinical and patient-related outcomes in pulmonary hypertension types i and iv
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617670/
https://www.ncbi.nlm.nih.gov/pubmed/34836178
http://dx.doi.org/10.3390/nu13113923
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