The Methionine 549 and Leucine 552 Residues of Friedelin Synthase from Maytenus ilicifolia Are Important for Substrate Binding Specificity

Friedelin, a pentacyclic triterpene found in the leaves of the Celastraceae species, demonstrates numerous biological activities and is a precursor of quinonemethide triterpenes, which are promising antitumoral agents. Friedelin is biosynthesized from the cyclization of 2,3-oxidosqualene, involving...

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Detalles Bibliográficos
Autores principales: Mazzeu, Bruna F., Souza-Moreira, Tatiana M., Oliveira, Andrew A., Remlinger, Melissa, Felippe, Lidiane G., Valentini, Sandro R., Guido, Rafael V. C., Zanelli, Cleslei F., Furlan, Maysa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617677/
https://www.ncbi.nlm.nih.gov/pubmed/34833897
http://dx.doi.org/10.3390/molecules26226806

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