A Review on the Evolving Roles of MiRNA-Based Technologies in Diagnosing and Treating Heart Failure

MiRNA-regulated processes are pivotal in cardiovascular homeostasis and disease. These short non-coding RNAs have ideal properties that could be utilized as potential biomarkers; moreover, their functions as post-transcriptional regulators of mRNA make them interesting therapeutic targets. In this r...

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Detalles Bibliográficos
Autores principales: Kennel, Peter J., Schulze, P. Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617680/
https://www.ncbi.nlm.nih.gov/pubmed/34831414
http://dx.doi.org/10.3390/cells10113191
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author Kennel, Peter J.
Schulze, P. Christian
author_facet Kennel, Peter J.
Schulze, P. Christian
author_sort Kennel, Peter J.
collection PubMed
description MiRNA-regulated processes are pivotal in cardiovascular homeostasis and disease. These short non-coding RNAs have ideal properties that could be utilized as potential biomarkers; moreover, their functions as post-transcriptional regulators of mRNA make them interesting therapeutic targets. In this review, we summarize the current state of miRNA-based biomarkers in a variety of diseases leading to heart failure, as well as provide an outlook on developing miRNA-based therapies in the heart failure field.
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spelling pubmed-86176802021-11-27 A Review on the Evolving Roles of MiRNA-Based Technologies in Diagnosing and Treating Heart Failure Kennel, Peter J. Schulze, P. Christian Cells Review MiRNA-regulated processes are pivotal in cardiovascular homeostasis and disease. These short non-coding RNAs have ideal properties that could be utilized as potential biomarkers; moreover, their functions as post-transcriptional regulators of mRNA make them interesting therapeutic targets. In this review, we summarize the current state of miRNA-based biomarkers in a variety of diseases leading to heart failure, as well as provide an outlook on developing miRNA-based therapies in the heart failure field. MDPI 2021-11-16 /pmc/articles/PMC8617680/ /pubmed/34831414 http://dx.doi.org/10.3390/cells10113191 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kennel, Peter J.
Schulze, P. Christian
A Review on the Evolving Roles of MiRNA-Based Technologies in Diagnosing and Treating Heart Failure
title A Review on the Evolving Roles of MiRNA-Based Technologies in Diagnosing and Treating Heart Failure
title_full A Review on the Evolving Roles of MiRNA-Based Technologies in Diagnosing and Treating Heart Failure
title_fullStr A Review on the Evolving Roles of MiRNA-Based Technologies in Diagnosing and Treating Heart Failure
title_full_unstemmed A Review on the Evolving Roles of MiRNA-Based Technologies in Diagnosing and Treating Heart Failure
title_short A Review on the Evolving Roles of MiRNA-Based Technologies in Diagnosing and Treating Heart Failure
title_sort review on the evolving roles of mirna-based technologies in diagnosing and treating heart failure
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617680/
https://www.ncbi.nlm.nih.gov/pubmed/34831414
http://dx.doi.org/10.3390/cells10113191
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