Cargando…

Long Term Metabolic and Inflammatory Effects of Second-Generation Antipsychotics: A Study in Mentally Disordered Offenders

Mentally disordered offenders provided with forensic psychiatric care are often treated with second generation antipsychotic (SGA) medication and experience metabolic and inflammatory side effects. Aim: In this paper, we monitored the three-year fluctuation of selected anthropometric, biochemical, a...

Descripción completa

Detalles Bibliográficos
Autores principales: Vassilopoulou, Emilia, Efthymiou, Dimitris, Papatriantafyllou, Evangelia, Markopoulou, Maria, Sakellariou, Efthymia-Maria, Popescu, Alina Codruta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617708/
https://www.ncbi.nlm.nih.gov/pubmed/34834541
http://dx.doi.org/10.3390/jpm11111189
_version_ 1784604570858553344
author Vassilopoulou, Emilia
Efthymiou, Dimitris
Papatriantafyllou, Evangelia
Markopoulou, Maria
Sakellariou, Efthymia-Maria
Popescu, Alina Codruta
author_facet Vassilopoulou, Emilia
Efthymiou, Dimitris
Papatriantafyllou, Evangelia
Markopoulou, Maria
Sakellariou, Efthymia-Maria
Popescu, Alina Codruta
author_sort Vassilopoulou, Emilia
collection PubMed
description Mentally disordered offenders provided with forensic psychiatric care are often treated with second generation antipsychotic (SGA) medication and experience metabolic and inflammatory side effects. Aim: In this paper, we monitored the three-year fluctuation of selected anthropometric, biochemical, and inflammatory indices in forensic psychiatric patients receiving antipsychotic (AP) medication for more than five years, according to the type of AP. Methods: Thirty-five patients with psychotic disorders were classified into two groups based on the type of AP. Specifically: AP1, related to a lower risk, and AP2, related to an increased risk of weight gain (WG) and metabolic complications. Biochemical, hematological, anthropometric, blood pressure (BP), and medication data were retrieved from the individual medical files. Statistical analysis was performed with SPSS 23. Results: No significant differences in weight and glucose and cholesterol levels were observed, but patients taking AP2 more often needed drugs to control diabetes mellitus (DM), lipidemia, and cardiovascular disease (CVD). In those taking AP1, the mean HDL level decreased significantly over time (p < 0.05) and a higher proportion developed higher BP (52.9% of AP1 vs. 16.7% AP2). In the AP2 group the median level of C-reactive protein (CRP) (p < 0.001) and the white blood cell count (WBC) increased over the three years (p < 0.001). Conclusions: The proposed sub-classification of SGAs into AP1 and AP2, depending on their potential for metabolic and inflammatory effects, might facilitate study of their long-term side-effects but also help in personalized prevention or treatment measures to counteract these side-effects.
format Online
Article
Text
id pubmed-8617708
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86177082021-11-27 Long Term Metabolic and Inflammatory Effects of Second-Generation Antipsychotics: A Study in Mentally Disordered Offenders Vassilopoulou, Emilia Efthymiou, Dimitris Papatriantafyllou, Evangelia Markopoulou, Maria Sakellariou, Efthymia-Maria Popescu, Alina Codruta J Pers Med Article Mentally disordered offenders provided with forensic psychiatric care are often treated with second generation antipsychotic (SGA) medication and experience metabolic and inflammatory side effects. Aim: In this paper, we monitored the three-year fluctuation of selected anthropometric, biochemical, and inflammatory indices in forensic psychiatric patients receiving antipsychotic (AP) medication for more than five years, according to the type of AP. Methods: Thirty-five patients with psychotic disorders were classified into two groups based on the type of AP. Specifically: AP1, related to a lower risk, and AP2, related to an increased risk of weight gain (WG) and metabolic complications. Biochemical, hematological, anthropometric, blood pressure (BP), and medication data were retrieved from the individual medical files. Statistical analysis was performed with SPSS 23. Results: No significant differences in weight and glucose and cholesterol levels were observed, but patients taking AP2 more often needed drugs to control diabetes mellitus (DM), lipidemia, and cardiovascular disease (CVD). In those taking AP1, the mean HDL level decreased significantly over time (p < 0.05) and a higher proportion developed higher BP (52.9% of AP1 vs. 16.7% AP2). In the AP2 group the median level of C-reactive protein (CRP) (p < 0.001) and the white blood cell count (WBC) increased over the three years (p < 0.001). Conclusions: The proposed sub-classification of SGAs into AP1 and AP2, depending on their potential for metabolic and inflammatory effects, might facilitate study of their long-term side-effects but also help in personalized prevention or treatment measures to counteract these side-effects. MDPI 2021-11-12 /pmc/articles/PMC8617708/ /pubmed/34834541 http://dx.doi.org/10.3390/jpm11111189 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vassilopoulou, Emilia
Efthymiou, Dimitris
Papatriantafyllou, Evangelia
Markopoulou, Maria
Sakellariou, Efthymia-Maria
Popescu, Alina Codruta
Long Term Metabolic and Inflammatory Effects of Second-Generation Antipsychotics: A Study in Mentally Disordered Offenders
title Long Term Metabolic and Inflammatory Effects of Second-Generation Antipsychotics: A Study in Mentally Disordered Offenders
title_full Long Term Metabolic and Inflammatory Effects of Second-Generation Antipsychotics: A Study in Mentally Disordered Offenders
title_fullStr Long Term Metabolic and Inflammatory Effects of Second-Generation Antipsychotics: A Study in Mentally Disordered Offenders
title_full_unstemmed Long Term Metabolic and Inflammatory Effects of Second-Generation Antipsychotics: A Study in Mentally Disordered Offenders
title_short Long Term Metabolic and Inflammatory Effects of Second-Generation Antipsychotics: A Study in Mentally Disordered Offenders
title_sort long term metabolic and inflammatory effects of second-generation antipsychotics: a study in mentally disordered offenders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617708/
https://www.ncbi.nlm.nih.gov/pubmed/34834541
http://dx.doi.org/10.3390/jpm11111189
work_keys_str_mv AT vassilopoulouemilia longtermmetabolicandinflammatoryeffectsofsecondgenerationantipsychoticsastudyinmentallydisorderedoffenders
AT efthymioudimitris longtermmetabolicandinflammatoryeffectsofsecondgenerationantipsychoticsastudyinmentallydisorderedoffenders
AT papatriantafyllouevangelia longtermmetabolicandinflammatoryeffectsofsecondgenerationantipsychoticsastudyinmentallydisorderedoffenders
AT markopouloumaria longtermmetabolicandinflammatoryeffectsofsecondgenerationantipsychoticsastudyinmentallydisorderedoffenders
AT sakellariouefthymiamaria longtermmetabolicandinflammatoryeffectsofsecondgenerationantipsychoticsastudyinmentallydisorderedoffenders
AT popescualinacodruta longtermmetabolicandinflammatoryeffectsofsecondgenerationantipsychoticsastudyinmentallydisorderedoffenders