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Parvovirus B19 in Croatia: A Large-Scale Seroprevalence Study
Background and Objectives: Seroepidemiological studies indicate that parvovirus B19 circulates in all areas of the world, although with some differences. The aim of this study is to analyze the seroprevalence of parvovirus B19 in the Croatian population. Materials and Methods: From 2010 to 2021, 153...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617724/ https://www.ncbi.nlm.nih.gov/pubmed/34833497 http://dx.doi.org/10.3390/medicina57111279 |
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author | Vilibic-Cavlek, Tatjana Tabain, Irena Kolaric, Branko Mihulja, Klara Blazevic, Lana Bogdanic, Maja Navolan, Dan Beader, Natasa Mrzljak, Anna |
author_facet | Vilibic-Cavlek, Tatjana Tabain, Irena Kolaric, Branko Mihulja, Klara Blazevic, Lana Bogdanic, Maja Navolan, Dan Beader, Natasa Mrzljak, Anna |
author_sort | Vilibic-Cavlek, Tatjana |
collection | PubMed |
description | Background and Objectives: Seroepidemiological studies indicate that parvovirus B19 circulates in all areas of the world, although with some differences. The aim of this study is to analyze the seroprevalence of parvovirus B19 in the Croatian population. Materials and Methods: From 2010 to 2021, 1538 serum samples from different populations were tested for the presence of parvovirus B19 IgM/IgG antibodies. Serological tests were performed using a commercial enzyme-linked immunosorbent assay. Results: IgG antibodies were detected in 986/64.1% of participants with differences (p < 0.001) among the following population groups: 42.4% of children and adolescents, 67.1% of the adult general population, 66.7% of hemodialysis patients, and 65.6% of liver transplant recipients. Seroprevalence increased with age, from 30.0% in the 6 months–9 years age group to 69.0% in the 40–49 years age group, and remained stable thereafter (68.8–73.3%). There was no difference in the seropositivity among males (66.1%) and females (63.1%), as well as the place of residence (suburban/rural 63.9%, urban 64.1%). IgM antibodies (current/recent infection) were found in 61/4.0% of participants with the highest seropositivity in the youngest age group (11.1%). In pregnant women, seroprevalence was higher in women with an unfavorable obstetric history compared with a normal pregnancy (IgG 71.0% vs. 62.6%; IgM 6.5% vs. 2.4%), but these differences were not significant. Logistic regression showed that the adult population had almost three times higher risk of IgG seropositivity compared to children/adolescents (general population OR = 2.777, 95% CI = 2.023–3.812; hemodialysis patients OR = 2.586, 95% CI = 1.531–4.367; and transplant patients OR = 2.717, 95% CI = 1.604–4.603). A one-year increase in age increased the risk of IgG seroprevalence (OR = 1.017; 95% CI = 1.011–1.022). Conclusions: Older age was the main risk factor for IgG seropositivity. Hemodialysis and organ transplantation seem unrelated to the increased parvovirus B19 seroprevalence. The role of parvovirus B19 in the etiology of TORCH infections needs to be studied further. |
format | Online Article Text |
id | pubmed-8617724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86177242021-11-27 Parvovirus B19 in Croatia: A Large-Scale Seroprevalence Study Vilibic-Cavlek, Tatjana Tabain, Irena Kolaric, Branko Mihulja, Klara Blazevic, Lana Bogdanic, Maja Navolan, Dan Beader, Natasa Mrzljak, Anna Medicina (Kaunas) Article Background and Objectives: Seroepidemiological studies indicate that parvovirus B19 circulates in all areas of the world, although with some differences. The aim of this study is to analyze the seroprevalence of parvovirus B19 in the Croatian population. Materials and Methods: From 2010 to 2021, 1538 serum samples from different populations were tested for the presence of parvovirus B19 IgM/IgG antibodies. Serological tests were performed using a commercial enzyme-linked immunosorbent assay. Results: IgG antibodies were detected in 986/64.1% of participants with differences (p < 0.001) among the following population groups: 42.4% of children and adolescents, 67.1% of the adult general population, 66.7% of hemodialysis patients, and 65.6% of liver transplant recipients. Seroprevalence increased with age, from 30.0% in the 6 months–9 years age group to 69.0% in the 40–49 years age group, and remained stable thereafter (68.8–73.3%). There was no difference in the seropositivity among males (66.1%) and females (63.1%), as well as the place of residence (suburban/rural 63.9%, urban 64.1%). IgM antibodies (current/recent infection) were found in 61/4.0% of participants with the highest seropositivity in the youngest age group (11.1%). In pregnant women, seroprevalence was higher in women with an unfavorable obstetric history compared with a normal pregnancy (IgG 71.0% vs. 62.6%; IgM 6.5% vs. 2.4%), but these differences were not significant. Logistic regression showed that the adult population had almost three times higher risk of IgG seropositivity compared to children/adolescents (general population OR = 2.777, 95% CI = 2.023–3.812; hemodialysis patients OR = 2.586, 95% CI = 1.531–4.367; and transplant patients OR = 2.717, 95% CI = 1.604–4.603). A one-year increase in age increased the risk of IgG seroprevalence (OR = 1.017; 95% CI = 1.011–1.022). Conclusions: Older age was the main risk factor for IgG seropositivity. Hemodialysis and organ transplantation seem unrelated to the increased parvovirus B19 seroprevalence. The role of parvovirus B19 in the etiology of TORCH infections needs to be studied further. MDPI 2021-11-21 /pmc/articles/PMC8617724/ /pubmed/34833497 http://dx.doi.org/10.3390/medicina57111279 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vilibic-Cavlek, Tatjana Tabain, Irena Kolaric, Branko Mihulja, Klara Blazevic, Lana Bogdanic, Maja Navolan, Dan Beader, Natasa Mrzljak, Anna Parvovirus B19 in Croatia: A Large-Scale Seroprevalence Study |
title | Parvovirus B19 in Croatia: A Large-Scale Seroprevalence Study |
title_full | Parvovirus B19 in Croatia: A Large-Scale Seroprevalence Study |
title_fullStr | Parvovirus B19 in Croatia: A Large-Scale Seroprevalence Study |
title_full_unstemmed | Parvovirus B19 in Croatia: A Large-Scale Seroprevalence Study |
title_short | Parvovirus B19 in Croatia: A Large-Scale Seroprevalence Study |
title_sort | parvovirus b19 in croatia: a large-scale seroprevalence study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617724/ https://www.ncbi.nlm.nih.gov/pubmed/34833497 http://dx.doi.org/10.3390/medicina57111279 |
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