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Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications
We designed and implemented a prospective study to analyze the maternal and neonatal outcomes associated with COVID-19 and determine the likelihood of viral transmission to the fetus and newborn by collecting samples from amniotic fluid, placenta, umbilical cord blood, and breast milk. The study fol...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617726/ https://www.ncbi.nlm.nih.gov/pubmed/34830532 http://dx.doi.org/10.3390/jcm10225253 |
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author | Citu, Cosmin Neamtu, Radu Sorop, Virgiliu-Bogdan Horhat, Delia Ioana Gorun, Florin Tudorache, Emanuela Gorun, Oana Maria Boarta, Aris Tuta-Sas, Ioana Citu, Ioana Mihaela |
author_facet | Citu, Cosmin Neamtu, Radu Sorop, Virgiliu-Bogdan Horhat, Delia Ioana Gorun, Florin Tudorache, Emanuela Gorun, Oana Maria Boarta, Aris Tuta-Sas, Ioana Citu, Ioana Mihaela |
author_sort | Citu, Cosmin |
collection | PubMed |
description | We designed and implemented a prospective study to analyze the maternal and neonatal outcomes associated with COVID-19 and determine the likelihood of viral transmission to the fetus and newborn by collecting samples from amniotic fluid, placenta, umbilical cord blood, and breast milk. The study followed a prospective observational design, starting in July 2020 and lasting for one year. A total of 889 pregnant women were routinely tested for SARS-CoV-2 infection in an outpatient setting at our clinic, using nasal swabs for PCR testing. A total of 76 women were diagnosed with COVID-19. The positive patients who accepted study enrollment were systematically analyzed by collecting weekly nasal, urine, fecal, and serum samples, including amniotic fluid, placenta, umbilical cord, and breast milk at hospital admission and postpartum. Mothers with COVID-19 were at a significantly higher risk of developing gestational hypertension and giving birth prematurely by c-section than the general pregnant population. Moreover, their mortality rates were substantially higher. Their newborns did not have negative outcomes, except for prematurity, and an insignificant number of newborns were infected with SARS-CoV-2 (5.4%). No amniotic fluid samples were positive for SARS-CoV-2, and only 1.01% of PCR tests from breast milk were confirmed positive. Based on these results, we support the idea that SARS-CoV-2 positive pregnant women do not expose their infants to an additional risk of infection via breastfeeding, close contact, or in-utero. Consequently, we do not support maternal–newborn separation at delivery since they do not seem to be at an increased risk of SARS-CoV-2 infection. |
format | Online Article Text |
id | pubmed-8617726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86177262021-11-27 Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications Citu, Cosmin Neamtu, Radu Sorop, Virgiliu-Bogdan Horhat, Delia Ioana Gorun, Florin Tudorache, Emanuela Gorun, Oana Maria Boarta, Aris Tuta-Sas, Ioana Citu, Ioana Mihaela J Clin Med Article We designed and implemented a prospective study to analyze the maternal and neonatal outcomes associated with COVID-19 and determine the likelihood of viral transmission to the fetus and newborn by collecting samples from amniotic fluid, placenta, umbilical cord blood, and breast milk. The study followed a prospective observational design, starting in July 2020 and lasting for one year. A total of 889 pregnant women were routinely tested for SARS-CoV-2 infection in an outpatient setting at our clinic, using nasal swabs for PCR testing. A total of 76 women were diagnosed with COVID-19. The positive patients who accepted study enrollment were systematically analyzed by collecting weekly nasal, urine, fecal, and serum samples, including amniotic fluid, placenta, umbilical cord, and breast milk at hospital admission and postpartum. Mothers with COVID-19 were at a significantly higher risk of developing gestational hypertension and giving birth prematurely by c-section than the general pregnant population. Moreover, their mortality rates were substantially higher. Their newborns did not have negative outcomes, except for prematurity, and an insignificant number of newborns were infected with SARS-CoV-2 (5.4%). No amniotic fluid samples were positive for SARS-CoV-2, and only 1.01% of PCR tests from breast milk were confirmed positive. Based on these results, we support the idea that SARS-CoV-2 positive pregnant women do not expose their infants to an additional risk of infection via breastfeeding, close contact, or in-utero. Consequently, we do not support maternal–newborn separation at delivery since they do not seem to be at an increased risk of SARS-CoV-2 infection. MDPI 2021-11-11 /pmc/articles/PMC8617726/ /pubmed/34830532 http://dx.doi.org/10.3390/jcm10225253 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Citu, Cosmin Neamtu, Radu Sorop, Virgiliu-Bogdan Horhat, Delia Ioana Gorun, Florin Tudorache, Emanuela Gorun, Oana Maria Boarta, Aris Tuta-Sas, Ioana Citu, Ioana Mihaela Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications |
title | Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications |
title_full | Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications |
title_fullStr | Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications |
title_full_unstemmed | Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications |
title_short | Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications |
title_sort | assessing sars-cov-2 vertical transmission and neonatal complications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617726/ https://www.ncbi.nlm.nih.gov/pubmed/34830532 http://dx.doi.org/10.3390/jcm10225253 |
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