Cargando…

Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications

We designed and implemented a prospective study to analyze the maternal and neonatal outcomes associated with COVID-19 and determine the likelihood of viral transmission to the fetus and newborn by collecting samples from amniotic fluid, placenta, umbilical cord blood, and breast milk. The study fol...

Descripción completa

Detalles Bibliográficos
Autores principales: Citu, Cosmin, Neamtu, Radu, Sorop, Virgiliu-Bogdan, Horhat, Delia Ioana, Gorun, Florin, Tudorache, Emanuela, Gorun, Oana Maria, Boarta, Aris, Tuta-Sas, Ioana, Citu, Ioana Mihaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617726/
https://www.ncbi.nlm.nih.gov/pubmed/34830532
http://dx.doi.org/10.3390/jcm10225253
_version_ 1784604575373721600
author Citu, Cosmin
Neamtu, Radu
Sorop, Virgiliu-Bogdan
Horhat, Delia Ioana
Gorun, Florin
Tudorache, Emanuela
Gorun, Oana Maria
Boarta, Aris
Tuta-Sas, Ioana
Citu, Ioana Mihaela
author_facet Citu, Cosmin
Neamtu, Radu
Sorop, Virgiliu-Bogdan
Horhat, Delia Ioana
Gorun, Florin
Tudorache, Emanuela
Gorun, Oana Maria
Boarta, Aris
Tuta-Sas, Ioana
Citu, Ioana Mihaela
author_sort Citu, Cosmin
collection PubMed
description We designed and implemented a prospective study to analyze the maternal and neonatal outcomes associated with COVID-19 and determine the likelihood of viral transmission to the fetus and newborn by collecting samples from amniotic fluid, placenta, umbilical cord blood, and breast milk. The study followed a prospective observational design, starting in July 2020 and lasting for one year. A total of 889 pregnant women were routinely tested for SARS-CoV-2 infection in an outpatient setting at our clinic, using nasal swabs for PCR testing. A total of 76 women were diagnosed with COVID-19. The positive patients who accepted study enrollment were systematically analyzed by collecting weekly nasal, urine, fecal, and serum samples, including amniotic fluid, placenta, umbilical cord, and breast milk at hospital admission and postpartum. Mothers with COVID-19 were at a significantly higher risk of developing gestational hypertension and giving birth prematurely by c-section than the general pregnant population. Moreover, their mortality rates were substantially higher. Their newborns did not have negative outcomes, except for prematurity, and an insignificant number of newborns were infected with SARS-CoV-2 (5.4%). No amniotic fluid samples were positive for SARS-CoV-2, and only 1.01% of PCR tests from breast milk were confirmed positive. Based on these results, we support the idea that SARS-CoV-2 positive pregnant women do not expose their infants to an additional risk of infection via breastfeeding, close contact, or in-utero. Consequently, we do not support maternal–newborn separation at delivery since they do not seem to be at an increased risk of SARS-CoV-2 infection.
format Online
Article
Text
id pubmed-8617726
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86177262021-11-27 Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications Citu, Cosmin Neamtu, Radu Sorop, Virgiliu-Bogdan Horhat, Delia Ioana Gorun, Florin Tudorache, Emanuela Gorun, Oana Maria Boarta, Aris Tuta-Sas, Ioana Citu, Ioana Mihaela J Clin Med Article We designed and implemented a prospective study to analyze the maternal and neonatal outcomes associated with COVID-19 and determine the likelihood of viral transmission to the fetus and newborn by collecting samples from amniotic fluid, placenta, umbilical cord blood, and breast milk. The study followed a prospective observational design, starting in July 2020 and lasting for one year. A total of 889 pregnant women were routinely tested for SARS-CoV-2 infection in an outpatient setting at our clinic, using nasal swabs for PCR testing. A total of 76 women were diagnosed with COVID-19. The positive patients who accepted study enrollment were systematically analyzed by collecting weekly nasal, urine, fecal, and serum samples, including amniotic fluid, placenta, umbilical cord, and breast milk at hospital admission and postpartum. Mothers with COVID-19 were at a significantly higher risk of developing gestational hypertension and giving birth prematurely by c-section than the general pregnant population. Moreover, their mortality rates were substantially higher. Their newborns did not have negative outcomes, except for prematurity, and an insignificant number of newborns were infected with SARS-CoV-2 (5.4%). No amniotic fluid samples were positive for SARS-CoV-2, and only 1.01% of PCR tests from breast milk were confirmed positive. Based on these results, we support the idea that SARS-CoV-2 positive pregnant women do not expose their infants to an additional risk of infection via breastfeeding, close contact, or in-utero. Consequently, we do not support maternal–newborn separation at delivery since they do not seem to be at an increased risk of SARS-CoV-2 infection. MDPI 2021-11-11 /pmc/articles/PMC8617726/ /pubmed/34830532 http://dx.doi.org/10.3390/jcm10225253 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Citu, Cosmin
Neamtu, Radu
Sorop, Virgiliu-Bogdan
Horhat, Delia Ioana
Gorun, Florin
Tudorache, Emanuela
Gorun, Oana Maria
Boarta, Aris
Tuta-Sas, Ioana
Citu, Ioana Mihaela
Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications
title Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications
title_full Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications
title_fullStr Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications
title_full_unstemmed Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications
title_short Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications
title_sort assessing sars-cov-2 vertical transmission and neonatal complications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617726/
https://www.ncbi.nlm.nih.gov/pubmed/34830532
http://dx.doi.org/10.3390/jcm10225253
work_keys_str_mv AT citucosmin assessingsarscov2verticaltransmissionandneonatalcomplications
AT neamturadu assessingsarscov2verticaltransmissionandneonatalcomplications
AT soropvirgiliubogdan assessingsarscov2verticaltransmissionandneonatalcomplications
AT horhatdeliaioana assessingsarscov2verticaltransmissionandneonatalcomplications
AT gorunflorin assessingsarscov2verticaltransmissionandneonatalcomplications
AT tudoracheemanuela assessingsarscov2verticaltransmissionandneonatalcomplications
AT gorunoanamaria assessingsarscov2verticaltransmissionandneonatalcomplications
AT boartaaris assessingsarscov2verticaltransmissionandneonatalcomplications
AT tutasasioana assessingsarscov2verticaltransmissionandneonatalcomplications
AT cituioanamihaela assessingsarscov2verticaltransmissionandneonatalcomplications