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SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism
Men are disproportionately affected by the coronavirus disease-2019 (COVID-19), and face higher odds of severe illness and death compared to women. The vascular effects of androgen signaling and inflammatory cytokines in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-mediated endotheli...
Autores principales: | Kumar, Nitin, Zuo, Yu, Yalavarthi, Srilakshmi, Hunker, Kristina L., Knight, Jason S., Kanthi, Yogendra, Obi, Andrea T., Ganesh, Santhi K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617813/ https://www.ncbi.nlm.nih.gov/pubmed/34835015 http://dx.doi.org/10.3390/v13112209 |
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