The Influence of Domain Permutations of an Albumin-Binding Domain-Fused HER2-Targeting Affibody-Based Drug Conjugate on Tumor Cell Proliferation and Therapy Efficacy

Human epidermal growth factor receptor 2 (HER2) is a clinically validated target for breast cancer therapy. Previously, a drug-fused HER2-targeting affinity protein construct successfully extended the survival of mice bearing HER2-expressing xenografts. The aim of this study was to evaluate the infl...

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Detalles Bibliográficos
Autores principales: Yin, Wen, Xu, Tianqi, Altai, Mohamed, Oroujeni, Maryam, Zhang, Jie, Vorobyeva, Anzhelika, Vorontsova, Olga, Vtorushin, Sergey V., Tolmachev, Vladimir, Gräslund, Torbjörn, Orlova, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617914/
https://www.ncbi.nlm.nih.gov/pubmed/34834389
http://dx.doi.org/10.3390/pharmaceutics13111974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617914/
https://www.ncbi.nlm.nih.gov/pubmed/34834389
http://dx.doi.org/10.3390/pharmaceutics13111974

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