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Preclinical Pharmacokinetics and Acute Toxicity in Rats of 5-{[(2E)-3-Bromo-3-carboxyprop-2-enoyl]amino}-2-hydroxybenzoic Acid: A Novel 5-Aminosalicylic Acid Derivative with Potent Anti-Inflammatory Activity

Compound 5-{[(2E)-3-bromo-3-carboxyprop-2-enoyl]amino}-2-hydroxybenzoic acid (C1), a new 5-aminosalicylic acid (5-ASA) derivative, has proven to be an antioxidant in vitro and an anti-inflammatory agent in mice. The in vivo inhibition of myeloperoxidase was comparable to that of indomethacin. The ai...

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Detalles Bibliográficos
Autores principales:	Gutiérrez-Sánchez, Mara, Romero-Castro, Aurelio, Correa-Basurto, José, Rosales-Hernández, Martha Cecilia, Padilla-Martínez, Itzia Irene, Mendieta-Wejebe, Jessica Elena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617944/ https://www.ncbi.nlm.nih.gov/pubmed/34833894 http://dx.doi.org/10.3390/molecules26226801

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