Cargando…

PCOS Phenotype in Unselected Populations Study (P-PUP): Protocol for a Systematic Review and Defining PCOS Diagnostic Features with Pooled Individual Participant Data

The diagnosis of polycystic ovary syndrome (PCOS) remains challenging due to limited data regarding normative cut-offs for the diagnostic features in different subpopulations. We aim to conduct a systematic review, build a comprehensive repository of de-identified individual participant data (IPD),...

Descripción completa

Detalles Bibliográficos
Autores principales: Kiconco, Sylvia, Mousa, Aya, Azziz, Ricardo, Enticott, Joanne, Suturina, Larisa V., Zhao, Xiaomiao, Gambineri, Alessandra, Tehrani, Fahimeh Ramezani, Yildiz, Bulent O., Kim, Jin-Ju, Teede, Helena J., Joham, Anju E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618006/
https://www.ncbi.nlm.nih.gov/pubmed/34829300
http://dx.doi.org/10.3390/diagnostics11111953
_version_ 1784604643636019200
author Kiconco, Sylvia
Mousa, Aya
Azziz, Ricardo
Enticott, Joanne
Suturina, Larisa V.
Zhao, Xiaomiao
Gambineri, Alessandra
Tehrani, Fahimeh Ramezani
Yildiz, Bulent O.
Kim, Jin-Ju
Teede, Helena J.
Joham, Anju E.
author_facet Kiconco, Sylvia
Mousa, Aya
Azziz, Ricardo
Enticott, Joanne
Suturina, Larisa V.
Zhao, Xiaomiao
Gambineri, Alessandra
Tehrani, Fahimeh Ramezani
Yildiz, Bulent O.
Kim, Jin-Ju
Teede, Helena J.
Joham, Anju E.
author_sort Kiconco, Sylvia
collection PubMed
description The diagnosis of polycystic ovary syndrome (PCOS) remains challenging due to limited data regarding normative cut-offs for the diagnostic features in different subpopulations. We aim to conduct a systematic review, build a comprehensive repository of de-identified individual participant data (IPD), and define normative ranges and diagnostic cut-offs for all PCOS diagnostic features. We will conduct a systematic search of MEDLINE and EMBASE databases for studies that assessed PCOS diagnostic features in unselected women. Two reviewers will assess eligibility and perform quality appraisal. Authors of included studies will be invited to contribute IPD. Primary variables include directly assessed modified Ferriman Gallwey (mFG) scores; menstrual cycle lengths; follicle number per ovary (FNPO), ovarian volume (OV), anti-Müllerian hormone (AMH); circulating androgens, including total testosterone (TT), free testosterone, bioavailable testosterone, free androgen index (FAI), androstenedione (A4), and dehydroepiandrosterone sulphate (DHEAS). Normative ranges and cut-offs will be defined using cluster analysis. Monash University Human Research Ethics Committee granted ethical approval (26938/0 1/12/2020), all IPD will be de-identified and primary studies have ethical approval from their institutional ethics committees. Findings will clarify distinction between PCOS and non-PCOS populations, and inform the update of the international evidence-based guidelines for the assessment and management of PCOS.
format Online
Article
Text
id pubmed-8618006
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86180062021-11-27 PCOS Phenotype in Unselected Populations Study (P-PUP): Protocol for a Systematic Review and Defining PCOS Diagnostic Features with Pooled Individual Participant Data Kiconco, Sylvia Mousa, Aya Azziz, Ricardo Enticott, Joanne Suturina, Larisa V. Zhao, Xiaomiao Gambineri, Alessandra Tehrani, Fahimeh Ramezani Yildiz, Bulent O. Kim, Jin-Ju Teede, Helena J. Joham, Anju E. Diagnostics (Basel) Protocol The diagnosis of polycystic ovary syndrome (PCOS) remains challenging due to limited data regarding normative cut-offs for the diagnostic features in different subpopulations. We aim to conduct a systematic review, build a comprehensive repository of de-identified individual participant data (IPD), and define normative ranges and diagnostic cut-offs for all PCOS diagnostic features. We will conduct a systematic search of MEDLINE and EMBASE databases for studies that assessed PCOS diagnostic features in unselected women. Two reviewers will assess eligibility and perform quality appraisal. Authors of included studies will be invited to contribute IPD. Primary variables include directly assessed modified Ferriman Gallwey (mFG) scores; menstrual cycle lengths; follicle number per ovary (FNPO), ovarian volume (OV), anti-Müllerian hormone (AMH); circulating androgens, including total testosterone (TT), free testosterone, bioavailable testosterone, free androgen index (FAI), androstenedione (A4), and dehydroepiandrosterone sulphate (DHEAS). Normative ranges and cut-offs will be defined using cluster analysis. Monash University Human Research Ethics Committee granted ethical approval (26938/0 1/12/2020), all IPD will be de-identified and primary studies have ethical approval from their institutional ethics committees. Findings will clarify distinction between PCOS and non-PCOS populations, and inform the update of the international evidence-based guidelines for the assessment and management of PCOS. MDPI 2021-10-21 /pmc/articles/PMC8618006/ /pubmed/34829300 http://dx.doi.org/10.3390/diagnostics11111953 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Protocol
Kiconco, Sylvia
Mousa, Aya
Azziz, Ricardo
Enticott, Joanne
Suturina, Larisa V.
Zhao, Xiaomiao
Gambineri, Alessandra
Tehrani, Fahimeh Ramezani
Yildiz, Bulent O.
Kim, Jin-Ju
Teede, Helena J.
Joham, Anju E.
PCOS Phenotype in Unselected Populations Study (P-PUP): Protocol for a Systematic Review and Defining PCOS Diagnostic Features with Pooled Individual Participant Data
title PCOS Phenotype in Unselected Populations Study (P-PUP): Protocol for a Systematic Review and Defining PCOS Diagnostic Features with Pooled Individual Participant Data
title_full PCOS Phenotype in Unselected Populations Study (P-PUP): Protocol for a Systematic Review and Defining PCOS Diagnostic Features with Pooled Individual Participant Data
title_fullStr PCOS Phenotype in Unselected Populations Study (P-PUP): Protocol for a Systematic Review and Defining PCOS Diagnostic Features with Pooled Individual Participant Data
title_full_unstemmed PCOS Phenotype in Unselected Populations Study (P-PUP): Protocol for a Systematic Review and Defining PCOS Diagnostic Features with Pooled Individual Participant Data
title_short PCOS Phenotype in Unselected Populations Study (P-PUP): Protocol for a Systematic Review and Defining PCOS Diagnostic Features with Pooled Individual Participant Data
title_sort pcos phenotype in unselected populations study (p-pup): protocol for a systematic review and defining pcos diagnostic features with pooled individual participant data
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618006/
https://www.ncbi.nlm.nih.gov/pubmed/34829300
http://dx.doi.org/10.3390/diagnostics11111953
work_keys_str_mv AT kiconcosylvia pcosphenotypeinunselectedpopulationsstudyppupprotocolforasystematicreviewanddefiningpcosdiagnosticfeatureswithpooledindividualparticipantdata
AT mousaaya pcosphenotypeinunselectedpopulationsstudyppupprotocolforasystematicreviewanddefiningpcosdiagnosticfeatureswithpooledindividualparticipantdata
AT azzizricardo pcosphenotypeinunselectedpopulationsstudyppupprotocolforasystematicreviewanddefiningpcosdiagnosticfeatureswithpooledindividualparticipantdata
AT enticottjoanne pcosphenotypeinunselectedpopulationsstudyppupprotocolforasystematicreviewanddefiningpcosdiagnosticfeatureswithpooledindividualparticipantdata
AT suturinalarisav pcosphenotypeinunselectedpopulationsstudyppupprotocolforasystematicreviewanddefiningpcosdiagnosticfeatureswithpooledindividualparticipantdata
AT zhaoxiaomiao pcosphenotypeinunselectedpopulationsstudyppupprotocolforasystematicreviewanddefiningpcosdiagnosticfeatureswithpooledindividualparticipantdata
AT gambinerialessandra pcosphenotypeinunselectedpopulationsstudyppupprotocolforasystematicreviewanddefiningpcosdiagnosticfeatureswithpooledindividualparticipantdata
AT tehranifahimehramezani pcosphenotypeinunselectedpopulationsstudyppupprotocolforasystematicreviewanddefiningpcosdiagnosticfeatureswithpooledindividualparticipantdata
AT yildizbulento pcosphenotypeinunselectedpopulationsstudyppupprotocolforasystematicreviewanddefiningpcosdiagnosticfeatureswithpooledindividualparticipantdata
AT kimjinju pcosphenotypeinunselectedpopulationsstudyppupprotocolforasystematicreviewanddefiningpcosdiagnosticfeatureswithpooledindividualparticipantdata
AT teedehelenaj pcosphenotypeinunselectedpopulationsstudyppupprotocolforasystematicreviewanddefiningpcosdiagnosticfeatureswithpooledindividualparticipantdata
AT johamanjue pcosphenotypeinunselectedpopulationsstudyppupprotocolforasystematicreviewanddefiningpcosdiagnosticfeatureswithpooledindividualparticipantdata