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Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?

The periosteum, with its outer fibrous and inner cambium layer, lies in a dynamic environment with a niche of pluripotent stem cells for their reparative needs. The inner cambium layer is rich in mesenchymal progenitors, osteogenic progenitors, osteoblasts, and fibroblasts in a scant collagen matrix...

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Autores principales: Jeyaraman, Madhan, Muthu, Sathish, Gangadaran, Prakash, Ranjan, Rajni, Jeyaraman, Naveen, Prajwal, Gollahalli Shivashankar, Mishra, Prabhu Chandra, Rajendran, Ramya Lakshmi, Ahn, Byeong-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618036/
https://www.ncbi.nlm.nih.gov/pubmed/34832915
http://dx.doi.org/10.3390/ph14111133
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author Jeyaraman, Madhan
Muthu, Sathish
Gangadaran, Prakash
Ranjan, Rajni
Jeyaraman, Naveen
Prajwal, Gollahalli Shivashankar
Mishra, Prabhu Chandra
Rajendran, Ramya Lakshmi
Ahn, Byeong-Cheol
author_facet Jeyaraman, Madhan
Muthu, Sathish
Gangadaran, Prakash
Ranjan, Rajni
Jeyaraman, Naveen
Prajwal, Gollahalli Shivashankar
Mishra, Prabhu Chandra
Rajendran, Ramya Lakshmi
Ahn, Byeong-Cheol
author_sort Jeyaraman, Madhan
collection PubMed
description The periosteum, with its outer fibrous and inner cambium layer, lies in a dynamic environment with a niche of pluripotent stem cells for their reparative needs. The inner cambium layer is rich in mesenchymal progenitors, osteogenic progenitors, osteoblasts, and fibroblasts in a scant collagen matrix environment. Their role in union and remodeling of fracture is well known. However, the periosteum as a source of mesenchymal stem cells has not been explored in detail. Moreover, with the continuous expansion of techniques, newer insights have been acquired into the roles and regulation of these periosteal cells. From a therapeutic standpoint, the periosteum as a source of tissue engineering has gained much attraction. Apart from its role in bone repair, analysis of the bone-forming potential of periosteum-derived stem cells is lacking. Hence, this article elucidates the role of the periosteum as a potential source of mesenchymal stem cells along with their capacity for osteogenic and chondrogenic differentiation for therapeutic application in the future.
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spelling pubmed-86180362021-11-27 Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future? Jeyaraman, Madhan Muthu, Sathish Gangadaran, Prakash Ranjan, Rajni Jeyaraman, Naveen Prajwal, Gollahalli Shivashankar Mishra, Prabhu Chandra Rajendran, Ramya Lakshmi Ahn, Byeong-Cheol Pharmaceuticals (Basel) Review The periosteum, with its outer fibrous and inner cambium layer, lies in a dynamic environment with a niche of pluripotent stem cells for their reparative needs. The inner cambium layer is rich in mesenchymal progenitors, osteogenic progenitors, osteoblasts, and fibroblasts in a scant collagen matrix environment. Their role in union and remodeling of fracture is well known. However, the periosteum as a source of mesenchymal stem cells has not been explored in detail. Moreover, with the continuous expansion of techniques, newer insights have been acquired into the roles and regulation of these periosteal cells. From a therapeutic standpoint, the periosteum as a source of tissue engineering has gained much attraction. Apart from its role in bone repair, analysis of the bone-forming potential of periosteum-derived stem cells is lacking. Hence, this article elucidates the role of the periosteum as a potential source of mesenchymal stem cells along with their capacity for osteogenic and chondrogenic differentiation for therapeutic application in the future. MDPI 2021-11-08 /pmc/articles/PMC8618036/ /pubmed/34832915 http://dx.doi.org/10.3390/ph14111133 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jeyaraman, Madhan
Muthu, Sathish
Gangadaran, Prakash
Ranjan, Rajni
Jeyaraman, Naveen
Prajwal, Gollahalli Shivashankar
Mishra, Prabhu Chandra
Rajendran, Ramya Lakshmi
Ahn, Byeong-Cheol
Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?
title Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?
title_full Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?
title_fullStr Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?
title_full_unstemmed Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?
title_short Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?
title_sort osteogenic and chondrogenic potential of periosteum-derived mesenchymal stromal cells: do they hold the key to the future?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618036/
https://www.ncbi.nlm.nih.gov/pubmed/34832915
http://dx.doi.org/10.3390/ph14111133
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