Cargando…
Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?
The periosteum, with its outer fibrous and inner cambium layer, lies in a dynamic environment with a niche of pluripotent stem cells for their reparative needs. The inner cambium layer is rich in mesenchymal progenitors, osteogenic progenitors, osteoblasts, and fibroblasts in a scant collagen matrix...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618036/ https://www.ncbi.nlm.nih.gov/pubmed/34832915 http://dx.doi.org/10.3390/ph14111133 |
_version_ | 1784604651075665920 |
---|---|
author | Jeyaraman, Madhan Muthu, Sathish Gangadaran, Prakash Ranjan, Rajni Jeyaraman, Naveen Prajwal, Gollahalli Shivashankar Mishra, Prabhu Chandra Rajendran, Ramya Lakshmi Ahn, Byeong-Cheol |
author_facet | Jeyaraman, Madhan Muthu, Sathish Gangadaran, Prakash Ranjan, Rajni Jeyaraman, Naveen Prajwal, Gollahalli Shivashankar Mishra, Prabhu Chandra Rajendran, Ramya Lakshmi Ahn, Byeong-Cheol |
author_sort | Jeyaraman, Madhan |
collection | PubMed |
description | The periosteum, with its outer fibrous and inner cambium layer, lies in a dynamic environment with a niche of pluripotent stem cells for their reparative needs. The inner cambium layer is rich in mesenchymal progenitors, osteogenic progenitors, osteoblasts, and fibroblasts in a scant collagen matrix environment. Their role in union and remodeling of fracture is well known. However, the periosteum as a source of mesenchymal stem cells has not been explored in detail. Moreover, with the continuous expansion of techniques, newer insights have been acquired into the roles and regulation of these periosteal cells. From a therapeutic standpoint, the periosteum as a source of tissue engineering has gained much attraction. Apart from its role in bone repair, analysis of the bone-forming potential of periosteum-derived stem cells is lacking. Hence, this article elucidates the role of the periosteum as a potential source of mesenchymal stem cells along with their capacity for osteogenic and chondrogenic differentiation for therapeutic application in the future. |
format | Online Article Text |
id | pubmed-8618036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86180362021-11-27 Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future? Jeyaraman, Madhan Muthu, Sathish Gangadaran, Prakash Ranjan, Rajni Jeyaraman, Naveen Prajwal, Gollahalli Shivashankar Mishra, Prabhu Chandra Rajendran, Ramya Lakshmi Ahn, Byeong-Cheol Pharmaceuticals (Basel) Review The periosteum, with its outer fibrous and inner cambium layer, lies in a dynamic environment with a niche of pluripotent stem cells for their reparative needs. The inner cambium layer is rich in mesenchymal progenitors, osteogenic progenitors, osteoblasts, and fibroblasts in a scant collagen matrix environment. Their role in union and remodeling of fracture is well known. However, the periosteum as a source of mesenchymal stem cells has not been explored in detail. Moreover, with the continuous expansion of techniques, newer insights have been acquired into the roles and regulation of these periosteal cells. From a therapeutic standpoint, the periosteum as a source of tissue engineering has gained much attraction. Apart from its role in bone repair, analysis of the bone-forming potential of periosteum-derived stem cells is lacking. Hence, this article elucidates the role of the periosteum as a potential source of mesenchymal stem cells along with their capacity for osteogenic and chondrogenic differentiation for therapeutic application in the future. MDPI 2021-11-08 /pmc/articles/PMC8618036/ /pubmed/34832915 http://dx.doi.org/10.3390/ph14111133 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jeyaraman, Madhan Muthu, Sathish Gangadaran, Prakash Ranjan, Rajni Jeyaraman, Naveen Prajwal, Gollahalli Shivashankar Mishra, Prabhu Chandra Rajendran, Ramya Lakshmi Ahn, Byeong-Cheol Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future? |
title | Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future? |
title_full | Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future? |
title_fullStr | Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future? |
title_full_unstemmed | Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future? |
title_short | Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future? |
title_sort | osteogenic and chondrogenic potential of periosteum-derived mesenchymal stromal cells: do they hold the key to the future? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618036/ https://www.ncbi.nlm.nih.gov/pubmed/34832915 http://dx.doi.org/10.3390/ph14111133 |
work_keys_str_mv | AT jeyaramanmadhan osteogenicandchondrogenicpotentialofperiosteumderivedmesenchymalstromalcellsdotheyholdthekeytothefuture AT muthusathish osteogenicandchondrogenicpotentialofperiosteumderivedmesenchymalstromalcellsdotheyholdthekeytothefuture AT gangadaranprakash osteogenicandchondrogenicpotentialofperiosteumderivedmesenchymalstromalcellsdotheyholdthekeytothefuture AT ranjanrajni osteogenicandchondrogenicpotentialofperiosteumderivedmesenchymalstromalcellsdotheyholdthekeytothefuture AT jeyaramannaveen osteogenicandchondrogenicpotentialofperiosteumderivedmesenchymalstromalcellsdotheyholdthekeytothefuture AT prajwalgollahallishivashankar osteogenicandchondrogenicpotentialofperiosteumderivedmesenchymalstromalcellsdotheyholdthekeytothefuture AT mishraprabhuchandra osteogenicandchondrogenicpotentialofperiosteumderivedmesenchymalstromalcellsdotheyholdthekeytothefuture AT rajendranramyalakshmi osteogenicandchondrogenicpotentialofperiosteumderivedmesenchymalstromalcellsdotheyholdthekeytothefuture AT ahnbyeongcheol osteogenicandchondrogenicpotentialofperiosteumderivedmesenchymalstromalcellsdotheyholdthekeytothefuture |