Cargando…

The Importance of 6-Aminohexanoic Acid as a Hydrophobic, Flexible Structural Element

6-aminohexanoic acid is an ω-amino acid with a hydrophobic, flexible structure. Although the ω-amino acid in question is mainly used clinically as an antifibrinolytic drug, other applications are also interesting and important. This synthetic lysine derivative, without an α-amino group, plays a sign...

Descripción completa

Detalles Bibliográficos
Autores principales: Markowska, Agnieszka, Markowski, Adam Roman, Jarocka-Karpowicz, Iwona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618066/
https://www.ncbi.nlm.nih.gov/pubmed/34830000
http://dx.doi.org/10.3390/ijms222212122
_version_ 1784604658275188736
author Markowska, Agnieszka
Markowski, Adam Roman
Jarocka-Karpowicz, Iwona
author_facet Markowska, Agnieszka
Markowski, Adam Roman
Jarocka-Karpowicz, Iwona
author_sort Markowska, Agnieszka
collection PubMed
description 6-aminohexanoic acid is an ω-amino acid with a hydrophobic, flexible structure. Although the ω-amino acid in question is mainly used clinically as an antifibrinolytic drug, other applications are also interesting and important. This synthetic lysine derivative, without an α-amino group, plays a significant role in chemical synthesis of modified peptides and in the polyamide synthetic fibers (nylon) industry. It is also often used as a linker in various biologically active structures. This review concentrates on the role of 6-aminohexanoic acid in the structure of various molecules.
format Online
Article
Text
id pubmed-8618066
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86180662021-11-27 The Importance of 6-Aminohexanoic Acid as a Hydrophobic, Flexible Structural Element Markowska, Agnieszka Markowski, Adam Roman Jarocka-Karpowicz, Iwona Int J Mol Sci Review 6-aminohexanoic acid is an ω-amino acid with a hydrophobic, flexible structure. Although the ω-amino acid in question is mainly used clinically as an antifibrinolytic drug, other applications are also interesting and important. This synthetic lysine derivative, without an α-amino group, plays a significant role in chemical synthesis of modified peptides and in the polyamide synthetic fibers (nylon) industry. It is also often used as a linker in various biologically active structures. This review concentrates on the role of 6-aminohexanoic acid in the structure of various molecules. MDPI 2021-11-09 /pmc/articles/PMC8618066/ /pubmed/34830000 http://dx.doi.org/10.3390/ijms222212122 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Markowska, Agnieszka
Markowski, Adam Roman
Jarocka-Karpowicz, Iwona
The Importance of 6-Aminohexanoic Acid as a Hydrophobic, Flexible Structural Element
title The Importance of 6-Aminohexanoic Acid as a Hydrophobic, Flexible Structural Element
title_full The Importance of 6-Aminohexanoic Acid as a Hydrophobic, Flexible Structural Element
title_fullStr The Importance of 6-Aminohexanoic Acid as a Hydrophobic, Flexible Structural Element
title_full_unstemmed The Importance of 6-Aminohexanoic Acid as a Hydrophobic, Flexible Structural Element
title_short The Importance of 6-Aminohexanoic Acid as a Hydrophobic, Flexible Structural Element
title_sort importance of 6-aminohexanoic acid as a hydrophobic, flexible structural element
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618066/
https://www.ncbi.nlm.nih.gov/pubmed/34830000
http://dx.doi.org/10.3390/ijms222212122
work_keys_str_mv AT markowskaagnieszka theimportanceof6aminohexanoicacidasahydrophobicflexiblestructuralelement
AT markowskiadamroman theimportanceof6aminohexanoicacidasahydrophobicflexiblestructuralelement
AT jarockakarpowicziwona theimportanceof6aminohexanoicacidasahydrophobicflexiblestructuralelement
AT markowskaagnieszka importanceof6aminohexanoicacidasahydrophobicflexiblestructuralelement
AT markowskiadamroman importanceof6aminohexanoicacidasahydrophobicflexiblestructuralelement
AT jarockakarpowicziwona importanceof6aminohexanoicacidasahydrophobicflexiblestructuralelement