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l-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat

Chronic sympathetic hyperactivity is known to affect metabolism and cause various organ damage including bladder dysfunction. In this study, we evaluated whether l-theanine, a major amino acid found in green tea, ameliorates bladder dysfunction induced by chronic sympathetic hyperactivity as a dieta...

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Autores principales: Matsuoka, Kanako, Akaihata, Hidenori, Hata, Junya, Tanji, Ryo, Honda-Takinami, Ruriko, Onagi, Akifumi, Hoshi, Seiji, Koguchi, Tomoyuki, Sato, Yuichi, Kataoka, Masao, Ogawa, Soichiro, Kojima, Yoshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618158/
https://www.ncbi.nlm.nih.gov/pubmed/34822436
http://dx.doi.org/10.3390/metabo11110778
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author Matsuoka, Kanako
Akaihata, Hidenori
Hata, Junya
Tanji, Ryo
Honda-Takinami, Ruriko
Onagi, Akifumi
Hoshi, Seiji
Koguchi, Tomoyuki
Sato, Yuichi
Kataoka, Masao
Ogawa, Soichiro
Kojima, Yoshiyuki
author_facet Matsuoka, Kanako
Akaihata, Hidenori
Hata, Junya
Tanji, Ryo
Honda-Takinami, Ruriko
Onagi, Akifumi
Hoshi, Seiji
Koguchi, Tomoyuki
Sato, Yuichi
Kataoka, Masao
Ogawa, Soichiro
Kojima, Yoshiyuki
author_sort Matsuoka, Kanako
collection PubMed
description Chronic sympathetic hyperactivity is known to affect metabolism and cause various organ damage including bladder dysfunction. In this study, we evaluated whether l-theanine, a major amino acid found in green tea, ameliorates bladder dysfunction induced by chronic sympathetic hyperactivity as a dietary component for daily consumption. Spontaneously hypertensive rats (SHRs), as an animal model of bladder dysfunction, were divided into SHR–water and SHR–theanine groups. After 6 weeks of oral administration, the sympathetic nervous system, bladder function, and oxidative stress of bladder tissue were evaluated. The mean blood pressure, serum noradrenaline level, and media-to-lumen ratio of small arteries in the suburothelium were significantly lower in the SHR–theanine than in the SHR–water group. Micturition interval was significantly longer, and bladder capacity was significantly higher in the SHR–theanine than in the SHR–water group. Bladder strip contractility was also higher in the SHR–theanine than in the SHR–water group. Western blotting of bladder showed that expression of malondialdehyde was significantly lower in the SHR–theanine than in the SHR–water group. These results suggested that orally administered l-theanine may contribute at least partly to the prevention of bladder dysfunctions by inhibiting chronic sympathetic hyperactivity and protecting bladder contractility.
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spelling pubmed-86181582021-11-27 l-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat Matsuoka, Kanako Akaihata, Hidenori Hata, Junya Tanji, Ryo Honda-Takinami, Ruriko Onagi, Akifumi Hoshi, Seiji Koguchi, Tomoyuki Sato, Yuichi Kataoka, Masao Ogawa, Soichiro Kojima, Yoshiyuki Metabolites Article Chronic sympathetic hyperactivity is known to affect metabolism and cause various organ damage including bladder dysfunction. In this study, we evaluated whether l-theanine, a major amino acid found in green tea, ameliorates bladder dysfunction induced by chronic sympathetic hyperactivity as a dietary component for daily consumption. Spontaneously hypertensive rats (SHRs), as an animal model of bladder dysfunction, were divided into SHR–water and SHR–theanine groups. After 6 weeks of oral administration, the sympathetic nervous system, bladder function, and oxidative stress of bladder tissue were evaluated. The mean blood pressure, serum noradrenaline level, and media-to-lumen ratio of small arteries in the suburothelium were significantly lower in the SHR–theanine than in the SHR–water group. Micturition interval was significantly longer, and bladder capacity was significantly higher in the SHR–theanine than in the SHR–water group. Bladder strip contractility was also higher in the SHR–theanine than in the SHR–water group. Western blotting of bladder showed that expression of malondialdehyde was significantly lower in the SHR–theanine than in the SHR–water group. These results suggested that orally administered l-theanine may contribute at least partly to the prevention of bladder dysfunctions by inhibiting chronic sympathetic hyperactivity and protecting bladder contractility. MDPI 2021-11-14 /pmc/articles/PMC8618158/ /pubmed/34822436 http://dx.doi.org/10.3390/metabo11110778 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Matsuoka, Kanako
Akaihata, Hidenori
Hata, Junya
Tanji, Ryo
Honda-Takinami, Ruriko
Onagi, Akifumi
Hoshi, Seiji
Koguchi, Tomoyuki
Sato, Yuichi
Kataoka, Masao
Ogawa, Soichiro
Kojima, Yoshiyuki
l-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat
title l-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat
title_full l-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat
title_fullStr l-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat
title_full_unstemmed l-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat
title_short l-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat
title_sort l-theanine protects bladder function by suppressing chronic sympathetic hyperactivity in spontaneously hypertensive rat
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618158/
https://www.ncbi.nlm.nih.gov/pubmed/34822436
http://dx.doi.org/10.3390/metabo11110778
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